A device, method and application for synthesizing drug-loaded metal organic framework materials based on microfluidic one-pot method

A metal-organic framework and microfluidic technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems of low drug loading efficiency and poor release of drug molecules, etc. Achieve high drug loading efficiency, ideal dissolution efficiency, and good reproducibility

Active Publication Date: 2021-07-13
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method usually results in low drug loading efficiency and fast or poor release of drug molecules

Method used

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  • A device, method and application for synthesizing drug-loaded metal organic framework materials based on microfluidic one-pot method
  • A device, method and application for synthesizing drug-loaded metal organic framework materials based on microfluidic one-pot method
  • A device, method and application for synthesizing drug-loaded metal organic framework materials based on microfluidic one-pot method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A device for synthesizing a drug metal organic skeleton material based on a microfluidic aperator, including syringe A 1, syringe B 2, syringe C 3, T-type connector A 4, T-connector B 5, stainless steel Capillary 6, PTFE capillary 7, constant temperature water bath 8 and collecting tanks 9. The syringe A 1, the syringe B 2 and the syringe C 3 is a normal medical syringe, a specification of 10 mL. The T-type connector A 4 and T-type connector B 5 respectively include two inlet ends and an outlet end, the syringe A 1 and the syringe B 2, respectively, respectively, two inlet terminal pipes of the T-connector A 4, respectively. . The stainless steel capillary 6 has an inner diameter of 0.1 mm, and the outlet end of the T-type connector A 4 is connected to one end of the stainless steel capillary 6. The other end of the stainless steel capillary 6 passes through an inlet end and the outlet end of the T-type connector B 5, and the inlet end of the stainless steel capillary 6 is ...

Embodiment 2

[0042] A device for synthesizing a drug metal organic skeleton material based on a microfluidic aperator, including syringe A 1, syringe B 2, syringe C 3, T-type connector A 4, T-connector B 5, stainless steel Capillary 6, PTFE capillary 7, constant temperature water bath 8 and collecting tanks 9. The syringe A 1, the syringe B 2 and the syringe C 3 is a normal medical syringe with a specification of 50 mL. The T-type connector A 4 and T-type connector B 5 respectively include two inlet ends and an outlet end, the syringe A 1 and the syringe B 2, respectively, respectively, two inlet terminal pipes of the T-connector A 4, respectively. . The stainless steel capillary 6 has an inner diameter of 0.3 mm, and the outlet end of the T-type connector A 4 is connected to one end of the stainless steel capillary 6. The other end of the stainless steel capillary 6 passes through an inlet end and the outlet end of the T-type connector B 5, and the inlet end of the stainless steel capillary 6...

Embodiment 3

[0049] The method of synthesizing metal organic skeleton material ZIF-8 empty shell material based on Example 2, the specific steps are as follows:

[0050] Building a device, ready to carry out: 0.1 mmol Zn (NO 3 ) 2 · 6h 2 O Soluble in 10 ml deionized water, transfer to syringe A 1; weigh 0.8 mmol 2-methylimidazole in 10 ml deionized water, transfer to syringe B 2; quantity to take a grade soybean oil 50 ml transfer to Syringe C 3.

[0051] Synthesis of ZIF-8 carrier empty shells in microfluidic control: At the same time, open the injection pump connected to the syringe A 1 and syringe B 2, set the flow rate of 25 μL / min, drive the inner phase pressurization through the T-type connector A 4 After mixing, the stainless steel capillary 6 flows, and after the inner phase press is stabilized, the injection pump connected to the syringe C 3 is turned on, and the flow rate is 100 μl / min, and the driving outer phase carrier flows into the T-connector B 5 flow. The inner phase react...

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Abstract

A device, method and application for synthesizing a drug-loaded metal-organic framework material based on a microfluidic one-pot method, belonging to the field of drug-loaded metal-organic framework material synthesis. The device comprises a syringe a, a syringe b, a syringe c, a T-type connector a, a T-type connector b, a stainless steel capillary, a PTFE capillary, a constant temperature water bath and a collection tank, and the syringe a and the syringe b are respectively connected to the T-type The T-connector a is also connected to the stainless steel capillary, the stainless steel capillary passes through the T-connector b and is inserted into the PTFE capillary, the PTFE capillary is connected to the T-connector b, and the syringe c is connected to the T-connector b The middle part of the PTFE capillary is placed in a constant temperature water bath, and the other end of the PTFE capillary is connected to the collection tank. The invention has the advantages that the reaction conditions can be precisely controlled, the reproducibility is good, and the drug molecules are encapsulated inside the carrier, the drug loading efficiency is high, and the drug release efficiency is good.

Description

Technical field [0001] The present invention belongs to the field of drug metal organic skeleton material synthesis, and specific to a method and method and method for synthesizing a metal organic skeleton material based on microfluidic aperation method. Background technique [0002] Zegelediimidazole skeleton material ZiF-8 composed of zinc ion and 2-methylimidazole (HMIM) is in the form of a metal organic skeleton material (MOFS) due to its orchestral structure, and has become a metal organic skeleton material (MOFS). Most, one of the most potential microporous materials, ZiF-8 exhibits a broad application prospect in the field of gas adsorption separation, catalysis, and in vivo delivery. In addition to the general advantage of such materials, ZIF-8 has the characteristics of hydrothermal stability and acid instability, which provides possible to construct a pH response drug delivery system. For example, there is a tumor intracellular environmental bleeding (pH 4.0-6.0), and t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/704A61K47/69A61K47/22A61P35/00
CPCA61K9/145A61K31/704A61K47/6949A61P35/00
Inventor 武法文刘策王志祥
Owner CHINA PHARM UNIV
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