Artificial saliva containing okra extract and preparation method and application thereof

Abstract

The invention discloses artificial saliva containing okra extract, a preparation method and application thereof, and relates to the field of biology. The artificial saliva comprises the following rawmaterials in percentage by mass: 0.05-1% of the okra extract, 0.025-0.074% of sodium carboxymethyl cellulose, 0.00917-0.0946% of electrolyte, 0.01-0.5% of preservative, the rest is water for injectionor purified water; the preparation method comprises the following steps: preparing citric acid buffer solution; adding the electrolyte, stirring and dissolving; adjusting the pH value of the solutionto 6.2-7.3; adding the okra extract, stirring and dissolving; adding the sodium carboxymethyl cellulose while stirring, stirring and dissolving; adding preservative; adding a pH regulator, adjustingthe pH value of the mixed solution to 6.2-7.3, and performing radiation sterilization to obtain the finished product. The artificial saliva containing the okra extract has the advantages that the physical property of the prepared artificial saliva is close to the saliva normally secreted by the human body, the friction coefficient is close to the saliva normally secreted by the human body, the moist feeling in the oral cavity can be maintained for a long time, the oral mucosa is protected, and the effect of oral cavity nursing is achieved; the artificial saliva containing the okra extract haspositive therapeutic effect on xerostomia.

Description

technical field [0001] The invention relates to the field of biology, in particular to artificial saliva containing okra extract and its preparation method and application. Background technique [0002] Xerostomia is the subjective feeling of dry mouth. Xerostomia refers to the state or feeling of dry mouth caused by decreased saliva secretion or composition changes. It is a common oral symptom caused by various factors, and it is not an independent disease. The prevalence of xerostomia is approximately 5.5%-46%, and the prevalence increases with age. According to reports, the disease is more common in postmenopausal women, the elderly, and patients with advanced cancer, and the incidence of xerostomia is about 30%-40% in the elderly population over the age of 65. Xerostomia usually includes dry mouth, foreign body sensation and burning sensation, loss of taste, red tongue and chapped lips. Relatively persistent and persistent dry mouth symptoms often have a serious impact ...

AI Technical Summary

Problems solved by technology

[0004] In the prior art, artificial saliva is often used to treat xerostomia. For example, Chinese patent CN101524363B discloses an artificial saliva. This patent mainly uses hypromellose to form hydrogen bonds, van der Waals forces and hydrophobic bond, so as to produce a certain biological mucoadhesive effect, and at the same time, due to the hydrophilicity of hypromellose, the water can stay on the surface of the oral mucosa for a longer time, so as to prolong the action time of artificial saliva to maintain the moist feeling of the mouth; However, since the main component of this patent is hypromellose, and excessive oral administration of hypromellose can cause diarrhea, it cannot be used for a long time and excessively

Chinese patent CN108169431A discloses a kind of artificial saliva and preparation method thereof, and the main raw material of this patent is magnesium chloride, calcium chloride, calcium chloride, potassium chloride, dipotassium hydrogen phosphate, potassium carbonate, sodium carboxymethyl cellulose and Ionized water, the patent mainly uses sodium carboxymethylcellulose to increase the viscosity of artificial saliva, but its therapeutic effect on dry mouth is general

[0005] In addition, artificial saliva in the prior art is generally preserved and preserved by adding preservatives, high-temperature sterilization, etc., such as Chinese patent CN105147818 B, which discloses an artificial saliva and a preparation method thereof. This patent uses high-pressure steam at 121°C to The prepared artificial saliva is sterilized, but high temperature has a certain influence on the viscosity of artificial saliva

China CN106466480 A discloses a kind of artificial saliva for preventing and treating radioactive xerostomia. Sterilization, but because the artificial saliva is in direct contact with the oral mucosa of the human body, and the sublingual mucosa of the human oral cavity has the characteristics of strong penetration and rapid absorption of drugs, so the sublingual mucosa of the human oral cavity has anti-inflammatory, antibacterial, and mouth-moistening properties in absorbing artificial saliva. When using ingredients, it will also absorb a large amount of preservatives, so it cannot be used for a long time and excessively

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