4-Amino quinazoline compound as well as preparation method and application thereof

Abstract

The invention relates to a 4-amino quinazoline compound as well as a preparation method and application thereof. The compound has a general formula I) as shown in the specification, a quinazoline compound is taken as a basis, an aromatic ring methylene is introduced into the system for synthesizing a series of aromatic ring-containing methylene substituted 4-amino quinazoline compounds, the compound has a good inhibiting effect on pathogenic bacteria of plants, and has a good inhibiting effect on pathogenic bacteria such as xanthomonas oryzae, Xanthomonas citri and the like.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a quinazoline compound substituted with an aromatic ring methylene group and a preparation method and application thereof. Background technique [0002] In recent years, plant bacterial diseases (such as rice bacterial blight and citrus canker, etc.) have occurred and become popular in my country on a large scale, and the main economic crop diseases have shown high frequency of occurrence, severe damage, wide occurrence range, and great difficulty in prevention and control. and other characteristics, which often cause great losses to my country's national economy, especially agricultural production, and the activity of existing commercial antibacterial agents (such as eclopyrazole, thiabylcopper, ketal, etc.) is not efficient enough, and it is urgent to find highly effective anti-plant disease bacteria active compounds, and on this basis, create new green pesticides wit...

AI Technical Summary

Problems solved by technology

[0002] In recent years, plant bacterial diseases (such as rice bacterial blight and citrus canker, etc.) have occurred and become popular in my country on a large scale, and the main economic crop diseases have shown high frequency of occurrence, severe damage, wide occurrence range, and great difficulty in prevention and control. and other characteristics, which often cause great losses to my country's national economy, especially agricultural production, and the activity of existing commercial antibacterial agents (such as eclopyrazole, thiabylcopper, ketal, etc.) is not efficient enough, and it is urgent to find highly effective anti-plant disease bacteria active compounds, and on this basis, create new green pesticides with independent intellectual property rights, providing candidate drugs for the prevention and control of bacterial diseases of crops

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