Novel quantitative mist doser for big and small mice

Abstract

The invention discloses a novel quantitative mist doser for big and small mice. The device comprises a breathing face mask and a storage jar, the breathing face mask is of a circular truncated cone structure, an air inlet is formed in the middle of the upper bottom of the breathing face mask, the upper bottom is communicated with an inner cavity at one end of the storage jar through a connecting piece, and a one-way valve used for inflowing of inhaled air is arranged at the air inlet; an air outlet is formed in the middle of the side surface of the breathing face mask, and a one-way used for exhausting of air is arranged at the air outlet; the breathing face mask is an elastic face mask capable of completely wrapping the heads of the big and small mice and oppositely fitting the heads andnose ends of the big and small mice; an air inlet communicated with an inner cavity of the storage jar is formed in the other end of the storage jar, and an air pushing control device capable of reciprocating along the inner cavity of the storage jar is arranged in the storage jar. The doser is convenient to operate, achieves quantitative control, can meet the requirements of in-vivo experiment studies and application of animals inhaling medicine, and is widely applied to scientific studies of occupational health, respiratory medicine and the like.

Description

technical field [0001] The invention relates to an atomized inhalation drug delivery device, in particular to a novel quantitative aerosol drug delivery device for rats and mice. Background technique [0002] Inhalation therapy is a topical drug, and the drug can directly reach the lesion without going through the blood circulation. It has the characteristics of small drug dose, high drug inhalation into the lungs, long drug deposition time, and good safety. At present, there are many kinds of aerosol drug delivery devices, and the common methods of use include direct use of aerosol for drug inhalation, aerosol plus inhalation aid, aerosol plus spacer for drug inhalation, etc. However, most of the current nebulized inhalation devices are designed for humans, and it is inconvenient to directly apply them to experimental animals. In the process of aerosol new drug development and pharmacological experimental research, the respiratory drug delivery device required for animal i...

AI Technical Summary

Problems solved by technology

However, most of the current aerosol inhalation devices are designed for humans, and it is inconvenient to apply them directly to experimental animals.

In the process of aerosol new drug development and pharmacological experimental research, the respiratory drug delivery device required for animal in vivo experiments is not perfect. Most of them place small animals in aerosol containers, and there are the following problems: (1) The activities of small animals are not restricted , it may affect the atomization effect because the mouth and nose are placed in the hidden parts of their own limbs or the position in the container is not easy to reach; (2) The airflow after atomization is unevenly distributed in the container where the small animal is, and it is different in different places. Insufficiency such as inconsistency in the amount of mist inhaled by small animals in the position affects the experimental results

However, compared with the device of the present invention, it is more complicated, the cost is high, and the experiment takes a long time

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