Application of L-type-voltage-gated-calcium-channel agonist to preparing medicine for treating mammal-bladder urinary dysfunction and evaluation method

A calcium ion channel and voltage-gated technology, which is applied in the direction of drug combinations, urinary system diseases, and active ingredients of heterocyclic compounds, can solve the problem of hindering urinary function, active urinary bladder, and lack of recognition of L-type voltage-gated calcium The role of ion channels and other issues to achieve the effect of increasing bladder urine capacity and reducing frequency of urination

Inactive Publication Date: 2019-05-14
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Failure to recognize the role of L-type voltage-gated calcium channels in the storage period
The blockade of L-type voltage-gated calcium ion channels may directly cause bladder smooth muscle to be unable to withstand the increasing intravesical pressure, resulting in a decrease in urine volume and manifested as an active bladder.
Based on these erroneous understandings, the current research on the mechanism of urinary function and the evaluation of drugs focus on the level of cells and tissues, and lack of a comprehensive evaluation system, which seriously hinders the research on the regulation of urinary function by corresponding drugs.

Method used

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  • Application of L-type-voltage-gated-calcium-channel agonist to preparing medicine for treating mammal-bladder urinary dysfunction and evaluation method
  • Application of L-type-voltage-gated-calcium-channel agonist to preparing medicine for treating mammal-bladder urinary dysfunction and evaluation method
  • Application of L-type-voltage-gated-calcium-channel agonist to preparing medicine for treating mammal-bladder urinary dysfunction and evaluation method

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Embodiment Construction

[0030] The present invention includes a method for regulating the contractility of bladder smooth muscle. The method includes injecting an effective dose of an L-type voltage-gated calcium ion channel agonist into a mammal in need. In this embodiment, the L-type voltage-gated calcium channel agonist is The ion channel is mainly its subunit Cav1.2.

[0031] The present invention also relates to a method for evaluating the regulation of L-type voltage-gated calcium ion channel agonists on bladder and urinary dysfunction in mammals. The specific method is as follows:

[0032] (1) Using isolated smooth muscle in vitro to determine that agonists of L-type voltage-gated calcium ion channels can increase the contractility of bladder smooth muscle;

[0033] (2) direct subcutaneous injection of an agonist of the L-type voltage-gated calcium ion channel to normal mammals to observe its regulating effect on bladder function under in vivo conditions;

[0034] (3) Selectively knock out o...

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Abstract

The invention provides application of an L-type-voltage-gated-calcium-channel agonist to preparing medicine for treating mammal-bladder urinary dysfunction and an evaluation method for the L-type-voltage-gated-calcium-channel agonist to adjust the mammal-bladder urinary dysfunction.

Description

technical field [0001] The invention relates to the application of L-type voltage-gated calcium ion channel agonist in the preparation of medicine for treating bladder and urinary dysfunction in mammals. [0002] The present invention also relates to a method for evaluating the regulation of L-type voltage-gated calcium ion channel agonists on bladder and urinary dysfunction in mammals. Background technique [0003] Urinary bladder dysfunction such as urinary frequency, urgency, nocturia, dysuria, overactive bladder syndrome, urinary incontinence, interstitial cystitis, drug-induced cystitis (ketamine cystitis), etc. affecting at least 50% of > 40 year old crowd. Current treatment options are limited and include: fluid intake control, drug control, use of adult diapers, and surgery. As far as drugs are concerned, there are currently: 1. First-line anticholinergic drugs, but the current oral dosage forms have limited curative effect and large side effects (most of them f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4418A61K31/40A61P13/10
CPCA61K31/40A61K31/4418A61K31/4422A61P13/00A61P13/10
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