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Natural anti-diuretic agent

An anti-diuretic and additive technology, applied in the field of medicine, can solve problems such as central nervous system adverse reactions, acute organ failure, abnormal liver function, etc., and achieve the effect of no toxic side effects, safe side effects, and fast onset of action

Active Publication Date: 2022-01-04
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that carbamazepine can cause adverse reactions in the central nervous system, and can also cause urticaria and abnormal liver function. In severe cases, it can cause hypersensitivity reactions in multiple organs throughout the body and lead to acute organ failure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Rats caffeine promote urination

[0028] 1, filling juice preparation:

[0029] Caffeine was prepared: prepared at a concentration of 5mg / ml, 10mg / ml, 20mg / ml solution of caffeine, labeled sequentially as low, medium and high dose groups caffeine, stored for use.

[0030] 2, experimental methods:

[0031] (1) groups of rats: the rats were divided into control, low, middle and high doses of caffeine treatment group, n = 6 rats, fasted water 12h.

[0032] (2) saline load: All rats are soft reduction causes abdominal bladder emptying, all rats fed with normal saline, each rat immediately after gavage returned to metabolic cages, each of the first recording in rats gavage time and marked as time zero. Each rats 30mL / kg physiological saline orally form water at time zero load.

[0033] (3) caffeine treatment: normal saline, after 30min, low, medium and high dose respectively intervention group caffeine 25mg / kg, 50mg / kg, 100mg / Preparation (1) In the step c...

Embodiment 2

[0044] Example 2 advance gavage theanine antagonize diuretic effect of caffeine

[0045] 1, filling juice preparation:

[0046] (1) Theanine was prepared: prepared at a concentration of 0.5mg / ml, 2.0mg / ml, theanine solution 8.0mg / ml, 32.0mg / ml, and stored for use at a water bath at 37 ℃ an ultrasonic homogenizer.

[0047] (2) of caffeine was prepared: solution prepared at a concentration of caffeine 20mg / ml, and stored for use.

[0048] 2, experimental methods:

[0049] (1) groups of rats: the rats were divided into blank control group, model group and caffeine 15mg / kg, 60mg / kg, 240mg / kg, 960mg / kg treatment group theanine, a total of six groups of six rats fasted water 12h.

[0050] (2) Animals treated: all rats were soft reduction causes abdominal bladder emptying, each rat was first fed recording time and the time labeled 0, each rat immediately after gavage in metabolic cages returned .

[0051] 0 time, caffeine model group rats 30mL / kg physiological saline ...

Embodiment 3

[0064] Example 3 simultaneously fed antagonistic effect of caffeine diuretic theanine

[0065] 1, theanine filling preparation of gastric juice:

[0066] (1) Theanine was prepared: prepared at a concentration of 0.5mg / ml, 2.0mg / ml, theanine solution 8.0mg / ml, 32.0mg / ml, and 37 ℃ water bath after an ultrasonic homogenizer, for use.

[0067] (2) of caffeine was prepared: solution prepared at a concentration of caffeine 20mg / ml, a mark 37 ℃ water bath after an ultrasonic homogenizer caffeine intervention, for use.

[0068] 2, experimental methods:

[0069] (1) groups of rats: the rats were divided into control group, model group and caffeine 15mg / kg, 60mg / kg, 240mg / kg, 960mg / kg treatment group theanine, a total of 6 groups, each large 6 rats, fasted water 12h.

[0070] (2) Animals treated: all rats were soft reduction causes abdominal bladder emptying, each rat was first fed recording time and the time labeled 0, each rat immediately after gavage in metabolic cages ...

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Abstract

The invention discloses a natural anti-diuretic agent, and belongs to the technical field of medicines. The invention provides a new strategy for preparing a antidiuretic drug by using theanine for the first time, and multi-level research verification is carried out. It is found that the theanine effectively antagonizes the diuretic effect of drugs such as caffeine, hydrochlorothiazide and furosemide, the theanine has the effect of inhibiting increase of the content of cardiac natriuretic peptide caused by the caffeine, the content of cardiac natriuretic peptide is reduced by about 1.4 times, the urination amount and urination times of rats are remarkably reduced within a certain period of time, the theanine has the advantages of being fast in effect taking, safe and free of toxic and side effects. According to the scheme, new use of old medicine can be realized, the time from medicine discovery to clinical transformation can be greatly shortened, and the application prospect is wide.

Description

Technical field [0001] The present invention relates to a natural anti-diuretic, it belongs to the technical field of medicine. Background technique [0002] Theanine (L-Theanine, molecular formula: C 7 Hide 15 N 2 O 3 ; Molecular weight: 174.20, CAS No: 3081-61-6), also known as N- ethyl -γ-L- glutamine, theanine native state are L-shaped. Theanine is a major and unique presence of free amino acid in tea, tea leaves dry weight content of about 1-2%, from green tea leaves first found in 1949, in follow-up studies confirmed that green tea, oolong tea, black tea are widespread. Theanine stable nature, the presence of white needle crystalline state at normal temperature, soluble in water. The study found that theanine has many biological functions, such as: antioxidant, protecting nerve cells, improve sleep, to provide attention and enhance cognitive abilities, the active prevention of liver injury. World Health Organization report that theanine safe. Previous studies have not found...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P7/12A23G1/42A23G3/36A23L2/52A23L21/10A23L33/175
CPCA61K31/198A61P7/12A23L33/175A23L2/52A23G1/42A23G3/364A23L21/10A23V2002/00A23V2200/30A23V2250/0646
Inventor 王一君宛晓春黄进宝阚志鹏温家强李欣杨云秋彭传燚唐晓宇
Owner ANHUI AGRICULTURAL UNIVERSITY
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