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Use of Vibrio succinates in medicines for preventing or treating altitude sickness

A technology for succinic vibrio and altitude sickness, applied in the field of biomedicine, can solve problems such as succinic vibrio that have not yet been seen

Active Publication Date: 2022-07-19
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no report on the application of succinic vibrio to altitude sickness

Method used

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  • Use of Vibrio succinates in medicines for preventing or treating altitude sickness
  • Use of Vibrio succinates in medicines for preventing or treating altitude sickness
  • Use of Vibrio succinates in medicines for preventing or treating altitude sickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1 Differences in the abundance of intestinal bacteria between the population in the plain area and the population in the plateau area

[0060] 1. Materials and methods:

[0061] 1.1 Study population

[0062] According to the STROBE statement, a case-control study was designed, and 128 Tibetan male soldiers who served in a certain army in China from a certain month of a certain year to a certain month in a certain year were included as the experimental group, and 128 plain Han soldiers were matched according to the age of the Tibetan soldiers. Compare. Strictly control the two groups of people to follow the same mixed diet of Chinese troops, maintain the same training environment and training intensity at an altitude of 3500 meters, and quit smoking and drinking for 3 months. Soldiers with chronic inflammatory disease, oral antibiotics, acute infections, and gastrointestinal disease were excluded.

[0063] 1.2 Fecal sample collection

[0064] Each research su...

Embodiment 2

[0087] Example 2 The effect of Succinivibrio dextrinosolvens on high altitude heart disease model rats

[0088] Experimental animals: SD rats, purchased from Beijing Weitong Lihua Laboratory Animal Co., Ltd.

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Abstract

The invention provides the application of Vibrio succinates in the preparation of medicines for preventing or treating altitude sickness, and the altitude sickness is acute altitude sickness and chronic altitude sickness generated in the altitude environment of more than 2000m.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to the application of Vibrio succinates in the preparation of medicines for preventing or treating altitude sickness. Background technique [0002] The plateau environment has thin air, low atmospheric pressure and oxygen partial pressure, cold and dry climate, and strong ultraviolet radiation. People who migrate from the plains to the plateau or stay in the plateau for a short period of time have a group of diseases characterized by hypoxia due to insufficient adaptability to the plateau environment, which is called altitude sickness. The symptoms are generally headache, palpitation, fatigue, chest tightness, shortness of breath, Vomiting, loss of appetite, convulsions, trance, sudden cognitive decline, etc. Signs are increased heart rate, deep breathing, mildly abnormal blood pressure, facial or limb edema, and cyanosis of the lips. [0003] At present, the commonly used drugs for the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/74A61P39/00A23L33/135
Inventor 何昆仑贾倩赵晓静刘继轩贾志龙石金龙张曼丽陈卉宁王依慧
Owner GENERAL HOSPITAL OF PLA
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