A kind of preparation method of pharmaceutical intermediate hexahydropyrene

Abstract

The invention discloses a preparation method of a pharmaceutical intermediate hexahydropyrene. After the coal tar raw material is pretreated, it undergoes hydrofining and hydrocracking reactions, and the resulting liquid is subjected to fractional distillation; the obtained diesel fraction enters the supplementary refining reaction zone, and undergoes hydrogenation saturation reaction under the action of supplementary refining catalyst; the supplementary refined product is cut , the resulting fractions were cooled and filtered to obtain high-purity hexadecahydropyrene. The present invention realizes for the first time the purpose of producing hexahydropyrene by using coal tar raw material through a hydrogenation process. Compared with the prior art, the method of the present invention obtains high-purity hexadecahydropyrene, and at the same time produces clean fuel oil and solvent oil products whose quality meets the requirements. The method of the invention improves the economical efficiency of coal tar processing, and has the characteristics of simple process and low operation energy consumption.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical intermediate hexahydropyrene. Background technique [0002] The production process of high-purity hexadecahydropyrene is harsh and expensive. Therefore, high-purity hexadecahydropyrene products that meet market requirements have become rare resources. [0003] At present, the synthetic method is one of the important ways to produce high-purity hexadecahydropyrene. Pyrene is an important component in coal tar, which is enriched in the fraction at 300-360 °C during the initial distillation of coal tar, and can be obtained through traditional rectification and crystallization methods. The raw material of coal tar basically does not contain hexadecahydropyrene, and the direct extraction of hexadecahydropyrene from coal tar has not been reported. The operation cost is high, and the extracted hexadecahydropyrene is low in purity and yield, making it economically unfeasible. The preparation o...

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Problems solved by technology

The raw material of coal tar basically does not contain hexadecahydropyrene, and there is no report on the direct extraction of hexadecahydropyrene from coal tar. The operating cost is high, and the extracted hexadecahydropyrene is low in purity and yield, which is economically unfeasible.

The preparation of 1,2,3,6,7,8-hexahydropyrene is generally mainly obtained through the selective catalytic hydrogenation of pyrene. Since the serial reactions and parallel reactions are carried out simultaneously, it is difficult to select a single product. Improvement, it is more difficult to obtain high-purity hexadecahydropyrene

[0004] CN1351130A introduces a method for producing diesel oil through hydrogenation of coal tar, mainly through fractionation of coal tar, and the fraction below the diesel oil obtained is subjected to hydrogenation refining, which can directly produce diesel oil that meets the fuel oil index or be used as a blending component of diesel products. However, it only hydrotreats the relatively light fractions in coal tar, and cannot extract high-value-added, high-purity cetylhydropyrene products, and does not fully utilize coal tar

Hexahydropyrene products cannot be extracted from the distillate, and only blended fuel oil is produced. The coal tar directly entering the high-temperature heating furnace in this process will cause coking of the furnace tube and affect the normal operation cycle of the device.

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