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Acoustic bioreactor processes

A bioreactor, acoustic technology, applied in the field of biological cell systems, can solve problems such as limiting attraction

Pending Publication Date: 2019-06-07
FLODESIGN SONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Acoustic bioreactor processes
  • Acoustic bioreactor processes
  • Acoustic bioreactor processes

Examples

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Embodiment Construction

[0036] The present disclosure can be understood more readily by reference to the following detailed description of the desired embodiment and the Examples included therein. In the following specification and claims that follow, reference will be made to a number of terms which shall be defined to have the following meanings.

[0037] Although specific terms are used in the following description for the sake of clarity, these terms are only intended to indicate specific structures of the illustrated embodiments selected for illustration in the drawings, and are not intended to define or limit the scope of the present disclosure. In the following drawings and the following description, it should be understood that like numerals refer to like functional components.

[0038] The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

[0039] The term "comprising" is used herein to require the presence of stated components and to...

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Abstract

A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid streamflows through the cell culture. The nutrient fluid stream dislodges some cells from the cell culture, which can then be recovered for cell therapy applications. The cell culture continues to expand and reproduce, permitting continuous recovery of cells from the bioreactor.

Description

Background technique [0001] The growth in the field of biotechnology is attributed to a number of factors, some of which include improvements in equipment available for bioreactors. Improvements in equipment have enabled the production of bio-derived materials such as monoclonal antibodies and recombinant proteins in larger volumes and at lower cost. One of the key components used in new bio-based pharmaceutical manufacturing methods is the bioreactor and its associated auxiliary methods. [0002] Modern bioreactors are very complex devices. It provides adjustment of fluid flow rate, gas content, temperature, pH and oxygen content, among other parameters. All of these parameters can be adjusted so that the cell culture produces the desired biomolecule from the bioreactor process as efficiently as possible. One method that has been used in the field of bioreactors is the perfusion method. The perfusion method is distinguished from the fed-batch method by its lower capital c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00B01D21/28
CPCB01D21/283C12M47/02C12M47/04
Inventor T·J·肯尼迪B·利普肯斯L·马西S·科瓦尔斯基C·莱德尔
Owner FLODESIGN SONICS