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Application and kit of hsa-mir-134-3p as a molecular marker for acute altitude sickness susceptible persons

A technology of molecular markers and altitude sickness, applied in the field of molecular biotechnology and its application, to achieve the effect of reducing health and life threats, strong reliability and large quantity

Active Publication Date: 2022-04-01
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on the correlation between circulating microRNAs and AMS susceptibility.

Method used

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  • Application and kit of hsa-mir-134-3p as a molecular marker for acute altitude sickness susceptible persons
  • Application and kit of hsa-mir-134-3p as a molecular marker for acute altitude sickness susceptible persons
  • Application and kit of hsa-mir-134-3p as a molecular marker for acute altitude sickness susceptible persons

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Correlation between the expression of microRNA in plasma samples and the risk of AMS

[0043] 1. Material and Specimen Collection Description

[0044] Plasma samples of AMS-susceptible individuals were collected from 209 AMS patients who entered the plateau rapidly before entering the plateau. Plasma samples of normal people were collected from 203 normal healthy people who entered the plateau rapidly before entering the plateau. The diagnosis of AMS was confirmed by the International Common Diagnostic Criteria-Lake Lewis Score. All the population did not take any preventive medicine before blood sampling. A total of 2ml of blood was collected in EDTA-Na anticoagulant tubes for each sample. The clinical case characteristics of the patients are shown in Table 1. This study has been approved by the Medical Ethics Committee of the Army Military Medical University (Third Military Medical University), and all specimens were collected with the informed consent o...

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Abstract

The invention relates to a microRNA marker for screening acute altitude sickness susceptible persons, the microRNA is hsa-miR-134-3p as a molecular marker for acute altitude sickness susceptible persons, which can be used in the preparation and screening of acute altitude sickness Applied in reagents or kits for susceptible persons. It also provides a kit for detecting the hsa-miR-134-3p molecule in human plain plasma by real-time fluorescent quantitative PCR method, and predicts the risk of acute altitude sickness by its expression level. As a molecular marker, the microRNA has the characteristics of strong specificity, high sensitivity, non-invasiveness, and convenience, and is suitable for large-scale screening of people susceptible to acute altitude sickness in plains.

Description

technical field [0001] The invention belongs to the field of molecular biotechnology and its application. The invention relates to the application and kit of hsa-miR-134-3p as a molecular marker for acute altitude sickness susceptible persons. Check the risk of acute altitude sickness. Therefore, it can be used to assess the susceptibility of the human body to acute altitude sickness and reduce the risk of acute altitude sickness. Background technique [0002] Acute mountain sickness (AMS) occurs in plain people who have lived in low-altitude areas for a long time, 1-3 days after entering the plateau quickly without adapting to the new environment, including headache, dizziness, fatigue, insomnia , Emotional restlessness, flatulence, diarrhea and vomiting and a series of symptoms, among which severe headache is a typical symptom of AMS. In geography, a vast area with an altitude higher than 500m and relatively flat or undulating terrain is called a plateau. In medicine, a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12Q1/6837C12N15/113
Inventor 高钰琪孙滨达张健阳黄河张刚张二龙陈建徐刚董华平柯贤峰
Owner ARMY MEDICAL UNIV