Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dressing for craniocerebral trauma and preparation method of dressing

A craniocerebral trauma, drug layer technology, applied in medical science, bandages, absorbent pads, etc., to achieve the effect of promoting wound healing, optimizing wound healing, and maintaining the wound environment

Active Publication Date: 2019-06-18
佳木斯大学附属第一医院
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Kaempferol-3-O-rhamnoside, also known as kaempferol-3-O-rhamnoside, also known as afudouside and afudouline, belongs to flavonoids. Modern pharmacological studies have shown that kaempferol-3-O-rhamnoside has anti-oxidation, liver protection, anti- Various activities such as thrombosis, but there is no report of applying kaempferol-3-O-rhamnoside to traumatic brain injury

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dressing for craniocerebral trauma and preparation method of dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: A kind of dressing for craniocerebral trauma

[0026] Kaempferol-3-O-rhamnoside 15g, average molecular weight is 2000, deacetylation degree is 10g chitosan 10g, average molecular weight is 60000, deacetylation degree is greater than 80% chitosan 10g, carbomer 2g, 6g glycerin, appropriate amount of glacial acetic acid, appropriate amount of 30% NaOH, add purified water to 100mL, and prepare according to the following method:

[0027] (1) Preparation of the drug layer: Weigh kaempferol-3-O-rhamnoside, chitooligosaccharides, carbomer and glycerin according to the amount, take 80mL of purified water, add carbomer, make it fully swell, and then add shell Polysaccharide and appropriate amount of glacial acetic acid, adjust the pH of the solution to 4.0-5.5, stir until the chitosan is completely dissolved, add kaempferol-3-O-rhamnoside, chitooligosaccharides and glycerin, add purified water to 100mL, stir After uniformity, use 30% NaOH to adjust the pH of the so...

Embodiment 2

[0029] Embodiment 2: A kind of dressing for craniocerebral trauma

[0030] Kaempferol-3-O-rhamnoside 25g, average molecular weight is 60000, chitosan 12g with degree of deacetylation greater than 80%, carbomer 2g, glycerin 8g, glacial acetic acid in right amount, 30% NaOH in right amount, add pure water to 100 mL, prepared according to the method of Example 1, to obtain the dressing for craniocerebral trauma of the present invention.

Embodiment 3

[0031] Embodiment 3: A kind of dressing for craniocerebral trauma

[0032] Kaempferol-3-O-rhamnoside 15g, average molecular weight is 2000, deacetylation degree is 91.6% chitooligosaccharide 10g, ciprofloxacin 2g, lidocaine 1g, average molecular weight is 60000, and deacetylation degree is greater than 10g of 80% chitosan, 2g of carbomer, 7g of glycerin, an appropriate amount of glacial acetic acid, an appropriate amount of 30% NaOH, add purified water to 100mL, prepare according to the method of Example 1, and obtain the craniocerebral trauma dressing of the present invention

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to dressing for craniocerebral trauma and a preparation method of the dressing. The dressing for craniocerebral trauma comprises a fixed layer, a backing layer as well as a waterabsorption layer and a drug layer which are arranged on the backing layer at an interval from outside to inside sequentially, wherein the drug layer comprises kaempferol-3-O-rhamnopyranoside, and a matrix of the drug layer is selected from alginate gel, cellulose gel, chitosan gel and the like. The dressing for craniocerebral trauma has the effect of promoting wound healing, and the effect of promoting wound healing is better when the matrix of the drug layer is chitosan gel containing chitosan oligosaccharide.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a dressing for craniocerebral trauma and a preparation method thereof. Background technique [0002] Traumatic brain injury refers to the injury caused by external violence directly or indirectly acting on the head, including scalp injury, skull injury and brain injury. damage. Traumatic brain injury mortality ranks first among traumatic deaths, accounting for more than 50% of traumatic deaths. [0003] Due to the special physiological structure of the scalp, after the scalp is torn, it has the characteristics of heavy bleeding and open wound, and it is easy to cause secondary infection and delay wound healing. In severe cases, it can cause intracranial infection and endanger the life and health of patients. . [0004] As a medical material covering wounds, medical dressings can replace the skin to act as a temporary barrier, control wound exudate, prevent external pathoge...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61F13/12A61F13/00A61L15/44A61L15/28
Inventor 宋广福王鹤遇常红方芳杨红伟
Owner 佳木斯大学附属第一医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com