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Use of Microorganisms to Identify and/or Differentiate Individuals of Different Ethnic Groups

A microbial and individual technology, applied in the field of biomedicine, can solve problems such as Acinetobacter bacteria that have not yet been seen

Active Publication Date: 2021-03-26
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no technical solution for identifying and / or distinguishing individuals of different ethnic groups using the Acinetobacter genus as a marker

Method used

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  • Use of Microorganisms to Identify and/or Differentiate Individuals of Different Ethnic Groups
  • Use of Microorganisms to Identify and/or Differentiate Individuals of Different Ethnic Groups
  • Use of Microorganisms to Identify and/or Differentiate Individuals of Different Ethnic Groups

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] 1.1 Study population

[0079] A case-control study was designed according to the STROBE statement, and 128 Tibetan male soldiers who served in a certain Chinese army from a certain month to a certain month in a certain year were included as the experimental group, and 128 plain Han soldiers were matched according to the age of the Tibetan soldiers. for comparison. Strictly control the two groups of people to have the same mixed diet of Chinese troops, maintain the same training environment and training intensity at an altitude of 3500 meters, quit smoking and drinking, and last for 3 months. Soldiers with chronic inflammatory diseases, oral antibiotics, acute infections, and gastrointestinal disorders were excluded.

[0080] 1.2 Stool sample collection

[0081] Each research subject received a toilet feces collector after being included. After excreting the stool, put the stool into a stool collection tube and store it in a -20°C refrigerator immediately. The next day...

Embodiment 2

[0105] Embodiment 2 verification experiment

[0106] Design a case-control study according to the STROBE statement, select 5 volunteers, and strictly control the 5 volunteers to have the same mixed diet of Chinese troops, maintain the same environment and exercise intensity at an altitude of 3500 meters, quit smoking and alcohol, and last for 3 months. Chronic inflammatory diseases, oral antibiotics, acute infections and gastrointestinal diseases were excluded in all 5 volunteers.

[0107] Experimental steps:

[0108] 1. Fecal sample collection;

[0109] 2. DNA extraction;

[0110] 3. PCR amplification, sample mixing and purification;

[0111] 4. Library construction and on-machine sequencing;

[0112] 5. Sequencing data processing;

[0113] 6. Operational taxon clustering and species annotation. The specific operations of steps 1-6 are as described in Example 1.

[0114] Experimental results

[0115] Among the 5 volunteers, 3 volunteers whose relative abundance value ...

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Abstract

The invention provides application of microorganisms in identification and / or differentiation of individuals of different races and application of a product for detecting the abundance of the microorganisms in identification and / or differentiation of individuals of different races, and also provides a method for identification and / or differentiation of individuals of different races. The method comprises the steps of detecting the relative abundance of Acinetobacter species in intestinal tract and / or feces of an individual, and comparing the relative abundance to a threshold value.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, in particular to the application of microorganisms in identifying and / or distinguishing individuals of different nationalities, and more specifically, to a method for detecting the relative abundance of the genus Acinetobacter and comparing it with a threshold to identify the ethnic origin of the individual. Background technique [0002] Altitude sickness, or altitude sickness, is a natural physiological response that occurs when a person reaches a certain altitude and the body adapts to changes in air pressure, low oxygen content, and dry air caused by altitude. The symptoms of altitude sickness are generally manifested as headache, palpitation, fatigue, chest tightness, shortness of breath, vomiting, loss of appetite, convulsions, trance, and sudden decline in cognitive ability. Signs include rapid heart rate, deep breathing, mildly abnormal blood pressure, edema of the face or limb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/06C12Q1/689C12R1/01
Inventor 何昆仑赵晓静刘继轩张泽宇崔赛嘉高晓健李晨刘春蕾
Owner GENERAL HOSPITAL OF PLA