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Freeze-dried composition for cosmetics and its preparation method

A technology for compositions and cosmetics, applied in the field of freeze-dried compositions and their preparation, can solve the problems of peeling of macromolecular polymers, excessive stickiness, poor skin feel, etc., and achieve good skin care effect, uniform appearance, The effect of high structural elasticity

Active Publication Date: 2022-02-01
张运适
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used freeze-drying excipients, such as glycosides, lactose, trehalose, carbomer, etc., when used in cosmetics, will have poor skin feel, excessive stickiness, and even macromolecular polymers peeling on the skin surface. to experience

Method used

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  • Freeze-dried composition for cosmetics and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Dissolve 0.01 g of sodium hyaluronate with a molecular weight of 2 million Daltons and 0.01 g of hydrolyzed fish skin collagen with a molecular weight of 10,000 Daltons in 99.98 g of water. After the dissolution is complete, take 2g of the mixture and add it to a 5ml vial, and pre-freeze the mixture at -30°C for 5 hours; after pre-freezing the mixture, sublimate in vacuum at -50°C for 20 hours; The heating rate of °C / min was increased to 400 min to obtain a semi-finished product of the freeze-dried composition; the semi-finished product of the freeze-dried composition was vacuum-dried at 30 °C for 2 hours. Finally, a fluffy and silver-white lustrous silk-like freeze-dried composition is obtained, and the freeze-dried composition can be recovered within 10% extrusion deformation rate. Add 2ml of purified water to the vial where the freeze-drying place is located, and the freeze-dried product will dissolve quickly, and it will not feel sticky when used on the skin.

Embodiment 2

[0034] Dissolve 0.5 g of sodium hyaluronate with a molecular weight of 1 million Daltons and 0.5 g of hydrolyzed fish skin collagen with a molecular weight of 10,000 Daltons in 99 g of water. After the dissolution is complete, take 2g of the mixture and add it to a 5ml vial, and pre-freeze the mixture at -30°C for 5 hours; after pre-freezing the mixture, sublimate in vacuum at -50°C for 20 hours; The heating rate of ℃ / min is raised for 400 minutes to obtain the semi-finished product of the freeze-dried composition; the semi-finished product of the freeze-dried composition is vacuum-dried at 30°C for 2 hours, and finally a fluffy and silky freeze-dried composition with silvery white luster is obtained, specifically as follows figure 1 shown. The lyophilized composition can be reconstituted within 25% extrusion set. Add 2ml of purified water to the vial where the freeze-drying place is located, and the freeze-dried product will dissolve quickly, and it will not feel sticky when...

Embodiment 3

[0036] Dissolve 0.5 g of sodium hyaluronate with a molecular weight of 100,000 Daltons and 0.5 g of hydrolyzed fish skin collagen with a molecular weight of 10,000 Daltons in 99 g of water. After the dissolution is complete, take 2g of the mixture and add it to a 5ml vial, and pre-freeze the mixture at -30°C for 5 hours; after pre-freezing the mixture, sublimate in vacuum at -50°C for 20 hours; The heating rate of °C / min was increased to 400 min to obtain a semi-finished product of the freeze-dried composition; the semi-finished product of the freeze-dried composition was vacuum-dried at 30 °C for 2 hours. Finally, a fluffy and silky silver-white lustrous freeze-dried composition is obtained. The freeze-dried composition has a brittle structure and breaks after being deformed. Add 2ml of purified water to the vial where the freeze-drying place is located, and the freeze-dried product will dissolve quickly, and it will not feel sticky when used on the skin.

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Abstract

A freeze-dried composition for cosmetics disclosed by the present invention comprises sodium hyaluronate and soluble protein, wherein the mass ratio of sodium hyaluronate to soluble protein is (1-50):(1-50). The freeze-dried composition of the present invention has a good skin care effect, acts on the skin without sticky feeling, forms a silky fluffy structure after freeze-drying, can quickly disintegrate and dissolve in a solvent, and sodium hyaluronate is in the silky fluffy structure It plays the role of skeleton support, has certain mechanical properties, and the filamentous fluffy structure is not easy to loose during transportation. The present invention also provides a method for preparing a freeze-dried composition used in cosmetics. Through a special preparation method, a freeze-dried composition with a fluffy filamentous structure can be prepared. Combining with the formula of the present invention, the quality of the freeze-dried composition can be taken into account. Mechanical properties and solubility, and the freeze-dried composition has both a more uniform shape and a higher structural elasticity.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a freeze-dried composition for cosmetics and a preparation method thereof. Background technique [0002] Freeze-drying technology refers to adding a binder to a flowable liquid, semi-solid or solid, or the flowable liquid, semi-solid or solid itself contains a binder, and then pouring it into a molding mold , a technology that is shaped by a freeze-drying process, and a preparation prepared by a freeze-drying excipient technology is called a freeze-dried excipient preparation. Since this type of preparation undergoes a freeze-drying process, it can protect heat-sensitive ingredients from being destroyed, so it has been widely used in fields such as orally disintegrating tablets, immediate-release tablets, chewable tablets, and special cosmetics. Commonly used freeze-drying excipients, such as glycosides, lactose, trehalose, carbomer, etc., when used in cosmetics, will have poor skin fee...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/65A61K8/64A61Q19/00
Inventor 张运适李梅
Owner 张运适
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