A kind of small-sized gadolinium-polyphenol polymer nanoparticle and its preparation method and application
A technology of polyphenolic polymers and nanoparticles, which can be used in preparations for in vivo tests, pharmaceutical formulations, drug delivery, etc., can solve problems such as limited applications, and achieve the effects of low synthesis cost, simple operation, and broad application prospects
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[0033] The preparation of small-sized gadolinium-polyphenol polymer nanoparticles proposed by the present invention is under weakly alkaline conditions, in a water / ethanol mixed solvent, with polyphenols as organic ligands and polymer monomers, and aldehydes as crosslinks agent to covalently crosslink polyphenols into polyphenol oligomers. Then add the metal precursor (containing Gd 3+ )Gd 3+ And polyphenol oligomers further coordinate cross-linking to form Gd-polyphenol polymer nanoparticles.
[0034] Concrete preparation method comprises the following steps:
[0035](1) Fully dissolve polyvinylpyrrolidone (PVP) in a certain proportion of water / ethanol mixed solvent, and adjust the pH value of the solution to 8-10. Add freshly prepared polyphenol solution and cross-linking agent solution in turn, and continue to stir at room temperature for 12-24h.
[0036] (2) Add Gd(NO 3 ) 3 solution, continue to stir for 12-24h, and then dialyze the prepared sample for 36-48h to remo...
Embodiment 1
[0043] (1) Accurately weigh 0.3g of polyvinylpyrrolidone (PVP-K30), add it to 35mL of ultrapure water and 10mL of absolute ethanol mixed solvent, add 0.3mL of ammonia water (25wt%) to adjust the pH to 8-10 after fully dissolving , a clear and transparent solution was obtained.
[0044] (2) Accurately weigh 0.20 g of tannic acid and dissolve it in 8 mL of ultrapure water, add it to the above solution, stir for a while, then add 3 mL of formaldehyde solution (3.7 wt %), and continue stirring for 12 h.
[0045] (3) Add 1 mL of freshly prepared Gd(NO 3 ) 3 Solution (2wt%) was stirred for 12 hours to obtain Gd-TA polymer nanoparticles.
[0046] (4) Dialysis through a dialysis membrane with a molecular cut-off of 14,000 for 48 hours to remove unreacted small molecules to purify the sample.
[0047] like figure 1 As shown, the Gd-TA polymer nanoparticles prepared in this example have an ultra-small particle size (average particle size is about 20.9 nm), and the particle size dist...
Embodiment 2
[0051] (1) Accurately weigh 0.3g of polyvinylpyrrolidone (PVP-K30), add it to 35mL of ultrapure water and 10mL of absolute ethanol mixed solvent, add 0.3mL of ammonia water (25wt%) to adjust the pH to 8-10 after fully dissolving , a clear and transparent solution was obtained.
[0052] (2) Accurately weigh 0.20 g of gallic acid (GA) and dissolve it in 8 mL of ultrapure water, add it to the above solution, stir for a while, then add 3 mL of formaldehyde solution (3.7 wt %), and continue stirring for 12 h.
[0053] (3) Add 1 mL of freshly prepared Gd(NO 3 ) 3 Solution (2wt%) was stirred for 12 hours to obtain Gd-GA polymer nanoparticles.
[0054] (4) Dialysis through a dialysis membrane with a molecular cut-off of 14,000 for 48 hours to remove unreacted small molecules to purify the sample.
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