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Semi-in-vivo animal experiment blood compatibility detecting system and application thereof

A hemocompatibility and animal experiment technology, applied in the field of hemocompatibility detection system for semi-in vivo animal experiments, can solve the problem of no simulation and monitoring of blood environment, avoid difficulties and ethical problems, reduce animal harm, and achieve the same high quality effect

Pending Publication Date: 2019-07-09
GUANGDONG GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The invention patent with the application number 201510234025.2 discloses "an experimental device for biological interventional materials in the semi-in vivo blood circulation environment", but the device in the scheme is not used to simulate and monitor the blood environment in animals: constant temperature, pressure, flow rate range

Method used

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  • Semi-in-vivo animal experiment blood compatibility detecting system and application thereof
  • Semi-in-vivo animal experiment blood compatibility detecting system and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The present invention provides a set of blood compatibility detection system for semi-in vivo animal experiments, which includes a heating device 1, a vessel 2, a hose, a pressure sensor 5, and a differential pressure flow sensor 6. The first flexible pipe 3, the other end of the first flexible pipe 3 is communicated with the bioengineering material (not shown in the vessel), and the other end of the bioengineering material is connected with the second flexible pipe 4 that can be connected to the distal end of the animal blood vessel; The engineering material is placed in the container 2, and the heating device 1 heats the bioengineering material, and the bioengineering material is a decellularized blood vessel, a tissue engineering blood vessel, a graft vessel used in arteriovenous fistula, a graft vessel used in bypass surgery, or a direct contact with blood The tubular implant material; the hose is provided with a pressure sensor 5 for measuring pressure and a differe...

Embodiment 2

[0027] This embodiment provides the application of the above-mentioned detection system in detecting the compatibility between bioengineering materials and blood. The first hose 3, the bioengineering material, the second hose 4, and the animal are constructed into a blood circulation channel. By adjusting the heating device 1 The heating temperature of the bioengineering material is obtained by using the pressure sensor 5 and the differential pressure flow sensor 6 to obtain the lumen pressure and the blood flow rate in the lumen of the bioengineering material.

Embodiment 3

[0029] This implementation provides the application of the blood compatibility detection system for the above-mentioned semi-in vivo animal experiment in detecting the burst pressure of bioengineering materials, injecting a flow medium into the first hose 3, applying pressure from the outside, blasting the bioengineering materials, and passing the pressure sensor 5 Obtain the burst pressure.

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Abstract

The invention discloses a semi-in-vivo animal experiment blood compatibility detecting system and application thereof. The detecting system comprises a heating device, a vessel, hoses, a pressure sensor and a differential pressure flow sensor, wherein the first hose, a bioengineering material, the second hose and an animal form a blood circulation loop. The semi-in-vivo animal experiment blood compatibility detecting system can control the experimental temperature at a stable value in real time and monitor the blood pressure and flow rate in the bioengineering material in real time, thereby better evaluating the vascular patency and blood compatibility.

Description

technical field [0001] The invention belongs to the field of biomedical material equipment, and in particular relates to a blood compatibility detection system for semi-in vivo animal experiments and its application. Background technique [0002] As the problem of population aging becomes more and more severe, more and more patients' tissues and organs are degraded. Coronary heart disease, hemodialysis, etc. need to be implanted with bioengineering materials, so the demand for bioengineering material implants has increased significantly. However, the direct contact between bioengineering materials and blood will stimulate the host defense mechanism, especially the blood stabilization mechanism, which will cause a cascade reaction, lead to thromboembolism, and endanger the lives of patients; and because bioengineering materials lack natural endothelial cells, blood coagulation is easier Formation of blood clots. Therefore, it is particularly important to study the blood com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/4851A61B2503/40
Inventor 林展翼梁远锋文章黄淑佩罗玮
Owner GUANGDONG GENERAL HOSPITAL
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