Method for predicting prognosis based on combined analysis of rectal cancer transcriptome genes and methylation and model application

A technology for methylation and rectal cancer, applied in the field of gene technology and medicine, can solve problems such as lack of specificity, lack of specific genes in detail, and difficulty in finding therapeutic targets, so as to solve clinical problems, improve accuracy, and reduce death rate effect

Active Publication Date: 2019-07-12
辽宁省肿瘤医院
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Problems solved by technology

However, there are still some problems with several existing screening methods: (1) Colonoscopy is invasive; (2) Single-gene prediction is not effective; (3) The clinical specificity of existing methylation markers and low sensitivity; (4) Lack of predictive models for joint analysis of transcriptome data and m

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  • Method for predicting prognosis based on combined analysis of rectal cancer transcriptome genes and methylation and model application
  • Method for predicting prognosis based on combined analysis of rectal cancer transcriptome genes and methylation and model application
  • Method for predicting prognosis based on combined analysis of rectal cancer transcriptome genes and methylation and model application

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[0026] Describe the present invention in detail below in conjunction with accompanying drawing and embodiment, the following description is only the preferred embodiment of the present invention, it should be pointed out that for those of ordinary skill in the art, without departing from the premise of the method of the present invention, can also make Several improvements and supplements should also be considered as the protection scope of the present invention.

[0027] Example Establishment of a rectal cancer prognosis risk prediction model based on differentially expressed genes and isomethylated genes and its application in predicting the prognosis of rectal cancer patients.

[0028] 1. Use the "edgeR package" in the R language to screen differentially expressed genes in rectal cancer samples and normal samples, draw heatmaps and volcano maps according to foldChange = 1, padj = 0.05, see figure 1 .

[0029] 2. Use the "edgeR package" in the R language for differential an...

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Abstract

The invention relates to the gene technology and medicine field, and in particular, relates to a method for predicting prognosis based on combined analysis of rectal cancer transcriptome genes and methylation and a model application. The invention provides an application of differentially expressed genes and differentially methylated genes in prognostic risk prediction of rectal cancer. The six special differentially expressed genes are TAMM41, AC022387.1, AP004609.1, GVQW3, AC245060.2 and AC027644.1. The seven special differential methylated genes are MIR7848, LRRC74B, MRPL13, SNRPD3, EMILIN2, NACAP1 and C8or87. The better choice is provided for early screening of rectal cancer, the accuracy of screening is improved, the mortality rate and local recurrence rate of rectal cancer patients are reduced, individualized and precise treatment is realized through the risk prediction model, and the prognosis of the patients is improved.

Description

technical field [0001] The invention relates to the fields of gene technology and medicine, in particular to a method and model application for predicting prognosis based on joint analysis of rectal cancer transcriptome gene and methylation. Background technique [0002] Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide and the fourth most common lethal tumor after lung, gastric, and liver cancers, with a poor prognosis. About one-third of people in developed countries die from the disease, and the five-year survival rate for rectal cancer in the United States is about 65 percent. Rectal cancer (RC) accounts for approximately 33% of colorectal cancer diagnoses and has a high rate of local recurrence. In general, the earlier the therapeutic intervention, the better the patient's prognosis. However, the lack of highly sensitive and specific biomarkers in current clinical work hinders the detection of patients with early rectal cancer to a cert...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/154C12Q2600/158Y02A90/10
Inventor 王哲解夕黎
Owner 辽宁省肿瘤医院
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