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Nerve cell protective agent and application thereof in epilepsy prevention and treatment

A technology of nerve cells and cells, applied in the prevention and treatment of epilepsy, in the field of oral tablets, can solve the problems of easy sticking and punching of tablets, and achieve the effect of solving easy sticking and punching, increasing dependence, significant social and economic significance

Active Publication Date: 2019-08-09
AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to facilitate the clinical use of the drug, the present invention finally obtains a drug preparation with good stability through a large number of experimental studies, which solves the problem that sodium valproate and ethambutol hydrochloride have strong hygroscopicity and cause problems when tableting. The problem of easy sticking

Method used

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  • Nerve cell protective agent and application thereof in epilepsy prevention and treatment
  • Nerve cell protective agent and application thereof in epilepsy prevention and treatment
  • Nerve cell protective agent and application thereof in epilepsy prevention and treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the preparation of ethambutol hydrochloride-sodium valproate tablet

[0025] (1) Weigh 10 g of ethambutol hydrochloride, add 200 mL of water to prepare a solution, then add 12 g of kaolin, continue to stir to make it fully adsorbed and mix evenly, dry at 50 ° C at low temperature, and pass through a 20-mesh sieve to obtain ethylamine hydrochloride Butanol-containing granules;

[0026] (2) Take sodium valproate 125g, add in 2L75% ethanol solution and be mixed with solution, then add kaolin 180g, keep stirring to make it fully adsorb and mix evenly, dry, cross 20 mesh sieves, obtain sodium valproate drug-containing granules;

[0027] (3) Mix ethambutol hydrochloride drug-containing granules, sodium valproate drug-containing granules with 50 g of calcium hydrogen phosphate, 20 g of sodium carboxymethyl starch and 3.2 g of magnesium stearate, and directly compress into tablets. During the tableting process, there is no sticking phenomenon. Measure the relea...

Embodiment 2

[0028] Embodiment 2: the preparation of ethambutol hydrochloride-sodium valproate tablet

[0029](1) Weigh 12.5g of ethambutol hydrochloride, add 250mL water to prepare a solution, then add kaolin 15g, keep stirring to make it fully adsorb and mix evenly, dry at 50°C at low temperature, and pass through a 20-mesh sieve to obtain ethanol hydrochloride Ambutol-containing granules;

[0030] (2) Take sodium valproate 125g, add in 2L75% ethanol solution and be mixed with solution, then add kaolin 200g, keep stirring to make it fully adsorb and mix evenly, dry, cross 20 mesh sieves, obtain sodium valproate drug-containing granules;

[0031] (3) Mix ethambutol hydrochloride drug-containing granules, sodium valproate drug-containing granules with 60 g of calcium hydrogen phosphate, 25 g of sodium carboxymethyl starch and 3.5 g of magnesium stearate, and directly compress into tablets. During the tableting process, there is no sticking phenomenon. Measure the release rate of medicin...

Embodiment 3

[0032] Embodiment 3: the preparation of ethambutol hydrochloride-sodium valproate tablet

[0033] (1) Weigh 15g of ethambutol hydrochloride, add 300mL of water to prepare a solution, then add 15g of kaolin, keep stirring to make it fully adsorbed and mix evenly, dry at 50°C at low temperature, and pass through a 20-mesh sieve to obtain ethylamine hydrochloride Butanol-containing granules;

[0034] (2) Take sodium valproate 125g, add in 2L75% ethanol solution and be mixed with solution, then add kaolin 200g, keep stirring to make it fully adsorb and mix evenly, dry, cross 20 mesh sieves, obtain sodium valproate drug-containing granules;

[0035] (3) Mix ethambutol hydrochloride drug-containing granules, sodium valproate drug-containing granules with 60 g of calcium hydrogen phosphate, 25 g of carboxymethyl starch sodium and 3.8 g of magnesium stearate, and directly compress into tablets. During the tableting process, there is no sticking phenomenon. Measure the release rate ...

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Abstract

The invention discloses a pharmaceutical preparation for protecting nerve cells. The pharmaceutical preparation is prepared from active components and medicinal auxiliary materials, wherein the activecomponents comprise an ethylamine butanol pharmaceutical salt, the medicinal auxiliary materials comprise white clay, and the weight ratio of the active components to the white clay is preferably 1:(1.3-2.5). By means of the pharmaceutical preparation, the problem of sticking during tabletting due to high hygroscopicity is solved, meanwhile, the stability of the preparation is enhanced, and the medicine can be slowly released in the body.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular relates to a solid oral preparation, in particular to an oral tablet for nerve cell protection and its application in the prevention and treatment of epilepsy. Background technique [0002] Epilepsy is a common neurological disease. It is a syndrome of chronic recurrent transient brain dysfunction, characterized by seizures caused by abnormal discharge of brain neurons. Among them, more than 30% of epilepsy patients are difficult to control their seizures with commonly used antiepileptic drugs in clinical practice, which is called intractable epilepsy. The pathogenesis of epilepsy is very complicated, and its entire mechanism has not been fully understood so far, but some important links of its pathogenesis have been discovered: the electrophysiological basis of epilepsy is highly synchronized abnormal discharge of neurons, and epilepsy is caused by The epilepto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/133A61K31/19A61K47/02A61K9/22A61P25/08
CPCA61K9/2009A61K31/133A61K31/19A61K47/02A61P25/08A61K2300/00
Inventor 王琳李扬宋进
Owner AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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