Hybrid peptide with immunomodulatory and anti-inflammatory functions and preparation method and application thereof

An immunomodulatory, hybrid peptide technology, applied in the field of genetic engineering and biological preparations, can solve the problems of increasing the complexity and antagonism of clinical drug selection, failing to improve the body's immune function, and reducing immunity and production performance, and achieving weight reduction. As well as intestinal damage, good immune and anti-inflammatory two-way regulation, and the effect of relieving tissue damage
CN110128544AActive Publication Date: 2019-08-16CHINA AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA AGRI UNIV
Publication Date
2019-08-16

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Abstract

The invention relates to the technical field of genetic engineering and biological preparation, in particular to a hybrid peptide having immunomodulating and anti-inflammatory functions, and a preparation method and an application thereof. The invention provides an immuno-anti-inflammatory hybrid peptide CTP, which is obtained by hybridization, optimization and screening of antibacterial peptide CATH-2 and thymosin TP5, and an amino acid sequence is shown as SEQ ID NO. 1. The hybrid peptide CTP has high bidirectional immunomodulatory activity, can enhance the immune function of the body undernormal or immunosuppressed state, and protects the body from damage caused by immunosuppression; in the inflammatory state, CTP can also inhibit the body's inflammatory response, alleviates the damageof an inflammatory reaction on the tissue, and has the advantages of low cytotoxicity, high safety, simple preparation method and low cost, can be used as an ideal immuno-anti-inflammatory regulator,and has good application potential and value.
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Description

technical field

[0001] The invention relates to the fields of genetic engineering and biological preparations, in particular to a hybrid peptide with immune regulation and anti-inflammatory functions, its preparation method and application. Background technique

[0002] When animals or humans are young, weak, disease, stress, pathogenic infection, etc., their immunity is often reduced, and then secondary infection (bacterial or viral mixed infection) occurs, causing inflammatory reactions (red, hot, swollen) , pain, etc.). At present, for the treatment of infection and inflammation, the traditional and commonly used prevention and treatment strategy is to use antibiotics and hormone anti-inflammatory drugs (such as hydrocortisone, dexamethasone, etc.), although it can effectively control infectious inflammation and non-infectious inflammation, However, continuous use can cause various side effects: such as serious disturbance of water and salt metabolism, sugar, fat, and pr...

Claims

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