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Medicine for treating Alzheimer's disease

A technology for Alzheimer's disease and drugs, applied in the field of drugs for the treatment of Alzheimer's disease, which can solve problems such as reduction in the number of synapses, autophagy disorders, neurofibrillary tangles, etc.

Active Publication Date: 2019-08-20
SHENZHEN UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the etiology of AD is complex, including senile plaques formed by Aβ protein aggregation, neurofibrillary tangles formed by hyperphosphorylated tau protein aggregation, decreased number of synapses, neuron loss, oxidative stress, mitochondrial damage, autophagy disorders, etc., and the course of the disease is long. At present, there is no drug that can fundamentally treat AD at home and abroad, so it is imminent to find a specific drug for AD
[0004] The pathogenesis of AD is very complex, and various mechanisms influence each other, so the effect of intervention from a single target is often not good

Method used

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  • Medicine for treating Alzheimer's disease
  • Medicine for treating Alzheimer's disease
  • Medicine for treating Alzheimer's disease

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Embodiment Construction

[0034] After a lot of research work, the present invention shows that curcumin (Curcumin), icariin (Icariin) and total ginsenosides have obvious intervention effects on the occurrence and development of AD, and the mechanism of action is different. Therefore, the present invention designs two kinds of traditional Chinese medicines Compound, and design different doses, to study the therapeutic effect of two groups of traditional Chinese medicine compound on AD and explore its molecular mechanism of action.

[0035] The ingredients of the present invention can use the extracts of these medicines, or can be extracted from the raw materials containing these ingredients by using the known method of decocting traditional Chinese medicines. The dosage for an adult weighing 60kg is: curcumin 450mg / d; fisetin 1200mg / d; piperine 2.5mg / d; icariin 300mg / d; total ginsenosides 175.5mg / d.

[0036] The content described below is that the present invention takes APP / PS1 double transgenic mouse...

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Abstract

The invention relates to a medicine for treating Alzheimer's disease. The medicine is prepared from the following components in parts by weight: 68-138 parts of curcumin, 0.4-0.8 part of piperine, 45-90 parts of icariin, 26-52 parts of total ginsenoside; or 180-360 parts of fisetin, 0.4-0.8 part of piperine, 45-90 parts of icariin and 26-52 parts of total ginsenoside. The medicine utilizes the characteristics of multi-target regulation and control of traditional Chinese medicines, and has great potential when applied to AD prevention and treatment.

Description

technical field [0001] The invention relates to a medicine for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) was first discovered and named by Alois Alzheimer in 1906. It is an age-related neurodegenerative disease, clinically manifested as memory loss and cognitive decline. As the main type of dementia in the elderly, AD has a very high morbidity and mortality rate in the elderly, and the incidence rate increases with age. Studies have shown that there are currently 50 million dementia patients in the world; it is predicted that by 2030, the number of patients will increase to 82 million, and by 2050, the number of patients will reach 152 million. [0003] With the development of the economy, my country has gradually entered an aging society, and the increase in the number of elderly people will inevitably lead to a further increase in AD patients, which will bring serious medical economic burden and social pressure. However, the eti...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P25/28A61K31/12A61K31/4525A61K31/7048
CPCA61K31/12A61K31/4525A61K31/7048A61K36/258A61P25/28A61K2300/00
Inventor 都秀波李雪霞倪嘉缵
Owner SHENZHEN UNIV
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