Application of butyric acid compound in preparing drug or functional food for treating ischemic stroke

A technology for ischemic stroke and functional food, applied in the field of medicine, can solve the problems of narrow treatment time window of only 4.5h, limited clinical application of r-tPA, unsatisfactory treatment effect, etc. The effect of restoring nerve function damage and improving dyslipidemia

Inactive Publication Date: 2019-08-23
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In my country’s guidelines for the prevention and treatment of cardiovascular and cerebrovascular diseases, intravenous injection of 0.9 mg/kg of recombinant tissue plasminogen activator (r-tPA) is recommended as the standard treatment for acute ischemic stroke, r -tPA is the only drug approved by the US FDA for intravenous thrombolysis, but its treatment time window is only 4.5 hours. Therefore, the vast majority of patients in my country cannot be effectively treated within the time window. Moreover, the application of r-tPA Reperfusion after thrombolysis can induce cascade reaction of free radic

Method used

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  • Application of butyric acid compound in preparing drug or functional food for treating ischemic stroke
  • Application of butyric acid compound in preparing drug or functional food for treating ischemic stroke
  • Application of butyric acid compound in preparing drug or functional food for treating ischemic stroke

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Embodiment 1

[0034] This embodiment provides a tablet with sodium butyrate as the main active ingredient of the drug, the concentration of sodium butyrate is 20-100 μM, and the effective dose of sodium butyrate as a drug is 5-50 mg / kg / d.

[0035] The preparation method is as follows: take food-grade sodium butyrate fine powder and starch, mix evenly, add appropriate amount of 10% starch slurry, make soft material, pass through a 16-mesh sieve to granulate. The wet granules were dried at 50°C, and the dry granules were passed through a 10-mesh sieve for granulation. Add lubricant magnesium stearate, mix well, and compress into tablets.

Embodiment 2

[0037] This embodiment provides a solution containing butyric acid, the concentration of butyric acid is 45mmol / L, and the effective dose of butyric acid as a drug is 32 mg / kg / d.

[0038] The preparation method is as follows: dilute food-grade butyric acid with sterilized water to obtain the product.

Embodiment 3

[0040] This embodiment provides a nutrient solution containing butyric acid, the concentration of butyric acid is 20-100 μM, and the effective dose of butyric acid as a drug is 5-50 mg / kg / d.

[0041] The preparation method is as follows: adding food-grade butyric acid into the nutrient solution, mixing evenly to obtain the product. Nutrient solution refers to a liquid preparation with buffer salt as the medium.

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Abstract

The invention discloses application of a butyric acid compound in preparing a drug or functional food for treating ischemic stroke. The drug or the functional food comprises the butyric acid compound,wherein the concentration of the butyric acid compound is 20-100 micromoles per liter, and the effective dose of the butyric acid compound as the drug is 5-50 mg/kg/d. After oral administration, thebutyric acid compound can effectively reduce the area of cerebral infarction, significantly restore the neurological damages caused by the ischemic stroke, ameliorate dyslipidemia caused by the ischemic stroke, and effectively reduce the blood viscosity, the fibrinogen content and the platelets aggregation rate, thereby ameliorating the complications induced by the ischemic stroke in many aspectsand effectively treating the ischemic stroke.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the application of a butyric acid compound in the preparation of medicine or functional food for treating ischemic stroke. Background technique [0002] Ischemic stroke (Cerebral ischemic stroke) is a central nervous system disease that seriously threatens human life and is characterized by high morbidity, disability and mortality. There are currently 70 million stroke patients in my country, including 2 million new patients each year, 20 million high-risk non-disabled patients, and a disability fatality rate of 30-40%. On average, one Chinese person has a stroke every 12 seconds. In 21 seconds, a Chinese dies of a stroke. Among stroke patients, ischemic stroke accounts for 69.6%, and ischemic stroke has become the disease with the highest mortality rate among Chinese residents. When the brain ischemia, acute hypoxia can lead to lack of energy metabolism, resulting in ischemic dam...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61K31/22A61P9/10A61P3/06A61P7/02A61P1/00A61P25/00A61P3/02A23L33/00
CPCA61K31/19A61K31/22A61P9/10A61P3/06A61P7/02A61P1/00A61P25/00A61P3/02A23L33/00A23V2002/00A23V2200/3262A23V2200/322A23V2200/32A23V2200/326A23V2250/02
Inventor 赵洁陈润芝徐影蔡铮吴芃
Owner SOUTHERN MEDICAL UNIVERSITY
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