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Determining a cancer prognosis

A technology for cancer and prognosis, applied in the direction of material inspection products, mass spectrometry, instruments, etc., can solve the problems of injury and inflammation, inappropriateness, and increased morbidity and mortality of NSCLC patients

Pending Publication Date: 2019-08-23
COUNCIL OF THE QUEENSLAND INST OF MEDICAL RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in NSCLC patients, comorbidities and general health problems make 20% of patients ineligible for such biopsies
In addition, biopsy itself may cause injury and inflammation, increasing morbidity and mortality in NSCLC patients

Method used

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  • Determining a cancer prognosis
  • Determining a cancer prognosis
  • Determining a cancer prognosis

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Experimental program
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Embodiment

[0143] Recent data suggest that tumor hypoxia is a powerful driver for the secretion of factors that promote metastatic dissemination 8,9 . A key component of secreted factors thought to be involved in enhancing metastasis is the release of exosomes. Accumulating evidence suggests that the rich array of proteomic and genomic information carried by tumor-derived exosomes is a novel mechanism by which cancer cells alter the behavior of surrounding stroma and malignant cells 10 . Exosomes Can Influence Participation in Neovascularization 11 , immunosuppressed 12 signaling process and induce drug resistance and oncogenic metastasis 13-15 . Furthermore, the ability of exosomes to induce systemic changes is thought to facilitate metastatic dissemination, which accounts for the vast majority of patient deaths 16 .

[0144] Exosomes have also been reported to transfer oncogenic proteins 14 . Exosome transfer in glioma cells has recently been shown to enhance tumorigenesis by ...

Embodiment 2

[0212] Despite significant therapeutic advances, lung cancer remains the leading cause of cancer-related death worldwide 1 . The overall five-year survival rate for patients with non-small cell lung cancer (NSCLC) is very poor, as low as 15% 2 . Biopsy is used to diagnose and type NSCLC, and TNM stage is the most important factor in predicting survival and guiding clinical intervention 2 . However, a large proportion of patients with early-stage and locally limited NSCLC have treatment-refractory disease or develop metastatic disease despite curative-intent treatment by surgical radiotherapy or chemoradiation, suggesting that TNM staging alone is insufficient to guide disease manage. Thus, there is a significant unmet clinical need to identify these patients who respond poorly to current treatments and allow tailored therapeutic interventions. Prognostic biomarkers, especially non-invasive fluid biomarkers, could allow clinicians to classify patients in need of intensive ...

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Abstract

The present invention provides methods of determining the aggressiveness, prognosis and response to therapy for cancer, such as non-small cell lung carcinoma (NSCLC), which includes determining an expression level of one or a plurality of differentially expressed protein markers in an exosome sample from a subject. A method and agent for treating cancer are also provided.

Description

technical field [0001] The present invention relates to cancer. More specifically, the present invention relates to methods of determining the prognosis of cancer, particularly lung cancer. Background technique [0002] Lung cancer is the leading cause of cancer death and disease burden in many countries. In Australia, for example, lung cancer accounts for 1 in 14 deaths in men and 1 in 25 deaths in women from any cause. Currently, for lung cancer, patients cannot be divided into responding and non-responding categories. [0003] Surgery is considered the best treatment for early-stage lung cancer in people who are good enough for surgical resection. Still, clinical staging is not perfect, as people treated by curative intent still have a high chance of relapse. For example, in stage I, II, or IIIA non-small cell lung cancer (NSCLC), despite potentially curative surgery, approximately 40% to 50% of patients with stage IB NSCLC, 55% to 70% of patients with stage II NSCLC ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/57423G01N2800/52G01N33/6893G01N2560/00
Inventor R·洛布A·莱姆格鲁伯A·穆勒
Owner COUNCIL OF THE QUEENSLAND INST OF MEDICAL RES