Nano drug carrier used for treating diabetes and composite medicine thereof

A technology of nano-medicine and medicine, applied in the cross field of nano-biology, biomimetic and bio-medicine
CN110179997AActive Publication Date: 2019-08-30CHINA SCI XINYUN BIOTECH BEIJING CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA SCI XINYUN BIOTECH BEIJING CO LTD
Publication Date
2019-08-30

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Abstract

The invention discloses a nano-drug delivery system used for sustained release of subcutaneous insulin. The drug delivery system comprises ferritin. The construction of insulin-ferritin sustained release drug delivery systems is based on self-assembly mediated by the hydrophilic and hydrophobic interaction of the ferritin with the insulin. Meanwhile, the internal cavity of the ferritin may be loaded with drugs such as insulin secretagogues agents, metformin, alpha-glycosidase inhibitors, thiazolidinedione derivatives and DPP-4 enzyme inhibitors. The novel protein nano-drug carrier has the advantages of low immunogenicity, biodegradability, high insulin and anti-blood glucose drug loading capacity, capability of obviously controlling blood glucose after one-time administration, capability of realizing mass production, and low cost. The drug carrier and the application thereof in diabetes have great social benefit and economic benefit, and also have good application prospect.
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Description

[0001] Technical field:

[0002] The invention belongs to the intersecting fields of nanobiology, bionics and biomedicine. In particular, the present invention discloses a nanometer drug delivery system that can load insulin and realize slow release of insulin subcutaneously, and the delivery system includes ferritin. Background technique

[0003] Diabetes mellitus is a chronic comprehensive disease mainly caused by the disorder of glucose metabolism caused by the absolute or relative deficiency of insulin, or the decreased sensitivity of target cells to insulin. The occurrence of type 2 diabetes is the combined effect of peripheral insulin resistance and Ξ²-cell dysfunction. the result of. Diabetes and its complications have become one of the most troublesome diseases in the world. According to the latest data released by the International Diabetes Federation, the number of adults with diabetes (20-79 years old) worldwide has reached 425 million in 2017, and it is estimated ...

Claims

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