Mussel bionic adhesive-calcium phosphate high-strength bone repair material, high-strength composite cap scaffold and preparation method thereof

Abstract

The invention belongs to the technical field of biological materials, and specifically relates to a mussel bionic binder-calcium phosphate high-strength bone repair material, a high-strength compositeCaP scaffold and a preparation method thereof. In view of the problems of insufficient strength, especially toughness, and insufficient printability and formability of bone repair materials in the prior art, the invention discloses the mussel bionic binder-calcium phosphate high-strength bone repair material and the preparation method thereof. The technical scheme is as follows: the mussel bionicbinder-calcium phosphate high-strength bone repair material is prepared from the following materials in parts by weight: 5-35 parts of a bionic binder, 65-95 parts of calcium phosphate salt and 95-105 parts of deionized water, wherein the bionic binder is prepared by dissolving 1-3 parts by weight of 3.4-dihydroxyphenylmethacrylamide in 10 parts by weight of a mixed solvent, and the calcium phosphate salt is prepared by mixing alpha-tricalcium phosphate, hydroxyapatite, calcium hydrogen phosphate dihydrate and calcium carbonate. The mussel bionic binder-calcium phosphate high-strength bone repair material is applicable to the repair of bone injury.

Description

Technical field [0001] The invention belongs to the technical field of medical biological materials, and specifically relates to a mussel bionic adhesive-calcium phosphate high-strength bone repair material, a high-strength composite CaP stent and a preparation method thereof. Background technique [0002] In the treatment of bone injury, synthetic bone repair materials are usually needed to reconstruct the normal structure and function of bone tissue. Synthetic bone repair materials need to have excellent mechanical properties (higher compressive strength, toughness and appropriate elasticity) to complete the functions of supporting body weight, maintaining posture and protecting internal organs. The low-crystalline calcium phosphate (CaP) porous scaffold that mimics bone tissue has excellent biocompatibility and osteoconductivity, and has been widely used in clinical bone repair. However, the current clinical use of CaP stents still faces the following problems: First, due to ...

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems of insufficient mechanical properties and insufficient printability and formability of bone repair materials in the prior art, the present invention provides a mussel biomimetic adhesive-calcium phosphate high-strength bone repair material, a high-strength composite CaP scaffold and a preparation method thereof. The purpose is to: improve the mechanical properties of the existing CaP bone repair materials, improve the printability of the bone repair materials in the prior art, and improve the coagulation and formability of the bone repair material slurry

Images