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Application of PPFIBP1 protein for preparing liver cancer postoperation prognosis evaluation kit

A 1. PPFIBP1, prognostic assessment technology, applied in the biological field, can solve the problem of liver cancer metastasis and recurrence affecting long-term efficacy and so on

Active Publication Date: 2019-09-10
昆山德诺瑞尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] With the advancement of diagnostic techniques and treatment methods, the curative effect has been improved in the past two decades, but the metastasis and recurrence of liver cancer is still an important obstacle affecting the long-term curative effect

Method used

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  • Application of PPFIBP1 protein for preparing liver cancer postoperation prognosis evaluation kit
  • Application of PPFIBP1 protein for preparing liver cancer postoperation prognosis evaluation kit
  • Application of PPFIBP1 protein for preparing liver cancer postoperation prognosis evaluation kit

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Embodiment 1

[0051] In this embodiment, tumor samples from 363 patients undergoing radical operation for liver cancer were collected and detected by the above-mentioned immunohistochemical method. The present invention detects in the tumor tissues of 363 routine liver cancer patients as follows: Figure 1-3 shown, where: figure 1 shows weak expression of PPFIBP1 in paracancerous tissues; figure 2 showed that PPFIBP1 was highly expressed in liver cancer tissues ( figure 2 ); image 3 The survival curves of patients with low expression of PPFIBP1 and patients with high expression of PPFIBP1 in liver cancer tissues are shown. Kaplan Meier survival curve analysis shows that the average survival time of patients with high expression of PPFIBP1 is significantly lower than that of patients with low expression of PPFIBP1.

[0052] Therefore, the expression level of PPFIBP1 protein is correlated with the recurrence and metastasis of liver cancer, and the detection of the expression level of PP...

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Abstract

The invention provides the application of PPFIBP1 protein for preparing a liver cancer postoperation prognosis evaluation kit. By use of the application, an immunohistochemical method is adopted to detect the relative expression quantity of the PPFIBP1 protein in a liver cancer tissue so as to judge the postoperation lifetime of a liver cancer patient. The beneficial effects of the invention are mainly embodied as follows: the invention provides the application of the PPFIBP1 protein for preparing the liver cancer postoperation prognosis evaluation kit, the protein can be prompted to be used for preparing a protein molecular marker used for judging liver cancer patient prognosis so as to perform an important guidance meaning for liver cancer patient postoperation monitoring.

Description

technical field [0001] The invention belongs to the field of biotechnology and relates to the application of a PPFIBP1 protein, in particular to the application of a PPFIBP1 protein in the preparation of a postoperative prognosis evaluation kit for liver cancer. Background technique [0002] Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, with 500,000 to 100,000 new cases each year worldwide, ranking fifth in the incidence of malignant tumors and third in the mortality rate. At present, the pathogenic factors of liver cancer have been identified, including hepatotropic virus infection, aflatoxin, alcohol, tobacco, and genetic metabolic liver disease. Depending on the differences in the exposure characteristics of different populations, the incidence of liver cancer varies from place to place. Most cases in high-end areas (such as Asia and Africa) are mainly caused by hepatitis B virus and hepatitis C virus infection, and the geographi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N33/531G01N33/532G01N33/558G01N33/574G01N33/576G01N33/68
CPCG01N33/5067G01N33/531G01N33/532G01N33/558G01N33/57438G01N33/5761G01N33/68Y02A90/10
Inventor 张鑫李国平
Owner 昆山德诺瑞尔生物科技有限公司
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