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Methods and compositions for adaptive immune modulation

A composition and allergen technology, applied in the direction of drug combination, pharmaceutical formula, allergic diseases, etc., can solve problems such as deficiencies

Pending Publication Date: 2019-09-13
BOARD OF RGT THE UNIV OF TEXAS SYST +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently available therapeutics for the treatment of allergic asthma provide immediate symptom relief, and some even reduce airway inflammation; however, they are still insufficient

Method used

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  • Methods and compositions for adaptive immune modulation
  • Methods and compositions for adaptive immune modulation
  • Methods and compositions for adaptive immune modulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0191] Example 1 Activation of lung innate immunity to regulate immune response in asthma

[0192] In the present study, the inventors investigated the possible role of inducible innate resistance in the regulation of the immune response in asthma using an experimental mouse model of asthma. Analysis of serum immunoglobulins and differential cell counts of bronchoalveolar lavage (BAL) fluid revealed that aerosol administration of O / P with OVA significantly reduced OVA-specific IgE levels as well as eosinophils in BAL. In contrast, the inventors observed an increase in serum IgG2a levels, a marker of Th1 immunity. Taken together, our findings suggest that activation of lung innate immunity with O / P in combination with specific antigens can switch allergic to non-allergic immune responses.

[0193] A. Results

[0194] Nebulized OVA-O / P decreased total IgE serum levels and OVA-IgE serum levels. Preliminary studies with aerosolized O / P have demonstrated a robust defense respons...

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PUM

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Abstract

Embodiments are directed to methods and compositions for modulating an immune response. In certain aspects the immune response is a type I hypersensitivity response. In particular aspects the subjecthas allergic asthma or allergic rhinitis. Using a conventional experimental asthma mouse model (BALB / c), the inventors demonstrate that aerosol administration of TLR agonists, in particular a combination of TLR2 / 6 and TLR9 agonist (e.g., TLR9 oligonucleotide agonist / PAM2CSK4) along with an antigen (e.g., ovalbumin (OVA)) suppresses the immune response as exemplified by the production of antigen-specific IgE and decreases the number of airway eosinophils in bronchoalveolar lavage fluid (BAL) in response to intra-peritoneal (IP) immunization with an antigen mixed with alum.

Description

[0001] This application claims priority to US Provisional Patent Application Serial No. 62 / 419,739, filed November 9, 2016, which is hereby incorporated by reference in its entirety. [0002] Statement Regarding Federally Funded Research [0003] This invention was made with government support under R43HL115903 awarded by the National Institutes of Health. The government has certain rights in this invention. [0004] Sequence Listing [0005] The sequence listing required by 37 CFR 1.821-1.825 is being filed electronically with this application. The Sequence Listing is incorporated herein by reference. [0006] Parties to a joint research agreement [0007] Certain embodiments described herein are the result of activities undertaken within the scope of joint research agreements in effect at the time this invention was made. The parties to the joint research agreement are the Board of Regents of the University of Texas System and the Texas A&M University System. Background...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P11/00A61P37/02A61P37/08
CPCA61K39/35A61K39/36A61K48/00A61K2039/544A61K2039/545A61P37/06A61P37/08H04B1/40H04B1/7156A61K2300/00C12N2310/315A61K38/164A61P11/06H04B1/713A61K38/08A61K2039/55561C12N15/117A61K31/7088A61K47/10H04B1/16A61K31/58H04B1/04H04B1/715
Inventor 伯顿·F·迪基迈克尔·J·图维姆斯科特·E·埃万斯马格努斯·胡克大卫·P·休斯顿玛加丽塔·马丁内斯-莫齐根巴布伦顿·斯科特
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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