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Schizophrenia biomarker combination based on intestinal flora and application and screening thereof

A biomarker and schizophrenia technology, which is applied in the field of kits for diagnosing or predicting the risk of schizophrenia, can solve the problems that the diagnosis of schizophrenia cannot achieve early warning, and cannot predict the onset and development trend of schizophrenia. Achieve the effect of improving efficiency and improving the efficiency of comparison

Pending Publication Date: 2019-09-17
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The problem to be solved by the present invention is to provide a biomarker combination for schizophrenia based on intestinal flora and its application, which can overcome the inability of the existing schizophrenia diagnosis to achieve early warning, the inability to predict the onset and development trend of schizophrenia, etc. Disadvantages, can help disease pathological classification and for drug target research, precise drug use, pathogenesis research, etc.

Method used

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  • Schizophrenia biomarker combination based on intestinal flora and application and screening thereof
  • Schizophrenia biomarker combination based on intestinal flora and application and screening thereof
  • Schizophrenia biomarker combination based on intestinal flora and application and screening thereof

Examples

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Embodiment 1

[0082] 1.1 Sample collection

[0083] Referring to the method described in the literature A metagenome-wide association study of gut microbiota in type2diabetes (Qin J et al. Nature.2012, 490, 55-60), the feces samples were collected and transported frozen and quickly transferred to -80°C for storage. Extract to obtain the extracted DNA sample. The stool samples of the schizophrenia and non-schizophrenia subjects of the present invention were from China. A total of 171 cases, including 81 healthy samples and 90 schizophrenic samples.

[0084] 1.2 Metagenome sequencing and assembly

[0085] The extracted DNA samples were used to construct a sequencing library, and two-way (Paired-end) metagenomic sequencing (insert fragment 350bp, read length 100bp) was performed on the Illumina HiSeq2000 sequencing platform. Filter the data generated by sequencing (quality-controlled), remove adapter contamination sequences, low-quality sequences and host genome contamination sequences, and...

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Abstract

The invention discloses a schizophrenia biomarker combination based on intestinal flora and application. Whether candidate medicines can be used for treating or preventing schizophrenia or not can be determined by utilizing the influences of the candidate medicines on the biomarker before and after use. The defects that an existing schizophrenia diagnosis method cannot achieve early-stage pre-warning, cannot predict the pathogenesis and development tendency of schizophrenia and the like. Therefore, the schizophrenia biomarker combination can be applied to predicting the pathogenesis and development tendency of schizophrenia and applied to preparation and application of a kit for disease pathological typing.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a biomarker of schizophrenia based on intestinal flora, a kit for diagnosing or predicting the risk of schizophrenia and its application. Background technique [0002] Schizophrenia (English: Schizophrenia) is a group of severe mental illnesses of unknown etiology, mostly in young adults with slow or subacute onset, clinically often manifested as a syndrome with various symptoms, involving perception, thinking, emotion and behavior Many other obstacles and incoordination of mental activities. Patients generally have clear consciousness and basically normal intelligence, but some patients will be accompanied by cognitive impairment during the course of the disease. The course of the disease is generally protracted, showing repeated attacks, aggravation or deterioration, and most patients eventually suffer from decline and mental disability, and only a small number of patients c...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12Q1/689C12N15/11
CPCC12Q1/6883C12Q1/689C12Q2600/136
Inventor 马现仓朱峰王崴范雅娟马青艳杨再赵斌斌杨林何潇言郭丽阳陈云春陈策高成阁
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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