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Pure natural compound essential oil with broad-spectrum bactericidal activity and preparation and application thereof

A technology of compound essential oil and bactericidal activity, which is applied in the fields of disinfection, sterilization and antisepsis. It can solve the problems of extraction and preparation methods and uses that have not been seen, and achieve the effects of low toxicity, low cost and wide sources.

Active Publication Date: 2019-10-11
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The bactericidal activity of Atractylodes atractylodes volatile oil and Guizhi volatile oil alone have been reported in the literature, but the bactericidal activity, extraction and preparation methods and uses of compound essential oils prepared from Atractylodes atractylodes and Guizhi volatile oil have not been found in relevant literature and patents

Method used

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  • Pure natural compound essential oil with broad-spectrum bactericidal activity and preparation and application thereof
  • Pure natural compound essential oil with broad-spectrum bactericidal activity and preparation and application thereof

Examples

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Effect test

preparation example Construction

[0032] One, the preparation of compound essential oil

[0033] Preparation process (1)

[0034] Extraction process of Atractylodes atractylodes: Crush the rhizome of Atractylodes atractylodes into dry powder, put them into a steam distillation extractor filled with 10 times the amount of water, control the temperature at around 100°C, and wait for about 6 hours when the liquid flowing down from the branch pipe of the extractor is colorless , that is, stop the extraction, remove the distilled water at the lower part with a separatory funnel to obtain an oily crude extract, seal it and store it in a refrigerator at 4°C for future use.

[0035] Cinnamon twig oil extraction process: Cinnamon twigs are crushed into dry powder, put into a steam distillation extractor filled with 12 times the amount of water, and the temperature is controlled at around 100°C. When the liquid flowing down the branch pipe of the extractor is colorless, about After 6 hours, the extraction was stopped, ...

Embodiment 1

[0065] The preparation of embodiment 1 two-component compound essential oil soft capsule

[0066] Formula (weight ratio): two-component compound essential oil 5.8%, soft capsule matrix: gelatin 17.7%, agar 17.7%, deionized water 58.8%.

[0067] Preparation method: put the above-mentioned soft capsule matrix in a chemical glue tank to make a glue solution, press it into soft capsules with a soft capsule machine, control the weight of each pill to 0.5g, and obtain 1000 two-component compound essential oil capsules.

Embodiment 2

[0068] The preparation of embodiment 2 two-component compound essential oil suppositories

[0069] Formula (weight ratio): two-component compound essential oil 5.9%, borneol 1.2%, suppository base: polyoxyethylene stearate 88.5%, polysorbate 80 4.4%.

[0070] Preparation method: Dissolve the borneol with an appropriate amount of ethanol, and then mix well with the two-component compound essential oil and polysorbate 80. In addition, melt polyoxyethylene stearate on a water bath, add the above liquid medicine, stir well, pour it into a suppository mold, take it out after cooling, and make 1000 capsules.

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Abstract

The invention discloses preparation and application of a pure natural compound essential oil with broad-spectrum bactericidal activity. The compound essential oil is obtained by extracting volatile oils from dry roots and stems of atractylodes lancea (Thunb.)DC. or atractylodes chinensis (DC.)Koidz. which belongs to atractylodes plants of the compositae family and dry twigs or bark of cinnamonum cassia Presl. which belongs to lauraceae plants, and then mixing and compounding the volatile oils, wherein the volume content of the atractylodes volatile oil is 40-70 parts, and the volume content ofthe cassia twig volatile oil is 30-60 parts. The compound essential oil can have a strong killing effect on staphylococcus aureus, escherichia coli and candida albicans.

Description

technical field [0001] The invention belongs to the technical fields of sterilization, disinfection and anticorrosion, and in particular relates to pure natural compound essential oil, a preparation method thereof, and applications in medical medicine, sanitation and disinfection products, food antisepsis and daily necessities. Background technique [0002] Rhizoma Atractylodis, also known as Chizhu, is the dry rhizome of Atractylodeslancea (Thunb.) DC. or Atractylodeschinensis (DC.) Koidz. of the genus Atractylodes in the family Asteraceae. Pungent in taste and warm in nature, it enters the spleen and stomach specifically, with the main functions of drying dampness and invigorating the spleen, expelling wind and dampness. Fumigation of the air with Atractylodes atractylodes has the effect of relieving stagnation and avoiding pollution, and its main bactericidal active ingredient is volatile oil. Atractylodes fumigation has been applied to wards, delivery rooms, and operati...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61P31/04A61P31/10A61P29/00A61K8/92A61Q17/00A01N65/24A01P1/00A23L3/3472
CPCA01N65/00A01N65/08A01N65/12A01N65/18A01N65/24A23L3/3472A23V2002/00A61K8/922A61K36/185A61K36/284A61K36/47A61K36/54A61K2236/331A61K2236/37A61K2800/5922A61K2800/805A61Q17/005A61P29/00A61P31/04A61P31/10A61K2300/00A23V2250/21Y02A50/30
Inventor 许旭东朱霄伟马国需朱乃亮
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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