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A hplc fingerprint detection method of Huagan decoction

A fingerprint and detection method technology, which is applied in the field of drug quality detection, can solve problems such as the influence of consistency between batches of quality, unstable medicinal materials, and complex ingredients, and achieve quality uniformity, many characteristic peaks, and simple detection methods. Effect

Active Publication Date: 2021-11-02
HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Huagan decoction has a long and rich history of human use in my country, but due to the instability of its medicinal materials and complex ingredients, the consistency of its quality between batches is easily affected, which is not conducive to the steady development of curative effect

Method used

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  • A hplc fingerprint detection method of Huagan decoction
  • A hplc fingerprint detection method of Huagan decoction
  • A hplc fingerprint detection method of Huagan decoction

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Experimental program
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Effect test

Embodiment 1

[0029] 1 material

[0030] 1.1 Instruments and reagents:

[0031] Instruments: Ultimate 3000 High Performance Liquid Chromatography (Thermo Fisher, Germany); DAD-3000 Diode Array Detector (Thermo Fisher, Germany); MS105DU Electronic Analytical Balance (Mettler-Toledo); KQ-300E Ultrasonic Cleaner Machine (Kunshan Ultrasonic Instrument Co., Ltd.); HH-S26S digital display constant temperature water bath, etc.

[0032] Reagents: acetonitrile, chromatographically pure (Merck); formic acid, chromatographically pure (Fisher); phosphoric acid, chromatographically pure (Kermel); ethanol, analytically pure (Kermel); Watsons purified water.

[0033] Paeoniflorin reference substance (batch number: 110736-201842, China National Institutes for Food and Drug Control);

[0034] Huagan decoction was provided by Henan Tailong Pharmaceutical Co., Ltd., and the batch number information is shown in Table 1.

[0035] Table 1 Batch number information of Huagan decoction

[0036] Number...

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Abstract

The invention discloses a method for detecting the HPLC fingerprint of Huaganjian. The high-performance liquid chromatography under specific conditions is used for detection, and the fingerprint with 8 common peaks is obtained, which can reflect the multi-component information of the product. The detection method is simple, with good reproducibility and many characteristic peaks, which can ensure the uniformity and stability of product quality. It can provide scientific basis for the quality control of the product.

Description

technical field [0001] The invention relates to a method for detecting the quality of medicines, in particular to a method for detecting HPLC fingerprints of Huaganjian. Background technique [0002] Huaganjian is an ancient classic recipe, which comes from Volume 51 of "Jingyue Quanshu" by Zhang Jingyue in the Ming Dynasty, Hanzheng. The original text of the prescription is: cure anger and damage the liver, so the qi is reversed and the fire is caused, resulting in syndromes such as dysphoria, hypochondriac pain, fullness and blood circulation. Qingpi and tangerine peel are 2 qian each, peony 2 qian, peony bark, gardenia (stir-fried), and Alisma alisma are 2 qian each, and Tu Fritillaria 2 and 3 qian. One and a half cups of water, fry for seven or eight minutes. Food away from warm clothes. [0003] This prescription has the functions of soothing the liver and relieving depression, clearing the liver and purging fire. It is used to treat anger that injures the liver, rev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/36
CPCG01N30/02G01N30/06G01N30/36G01N2030/047
Inventor 郭中华张立壮陈洁忠其木格张志平刘伟伟胡宇
Owner HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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