Application of amlexanox in relieving experimental autoimmune encephalomyelitis (EAE), and experiment method
A technology of aminolexanol and aminolezanol, applied in the field of medicine, can solve problems such as unresearched
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[0038] The present invention will be described in further detail below.
[0039] The application of amlexanox in alleviating the onset of EAE, reducing the degree of spinal cord inflammatory cell infiltration and demyelination.
[0040] Amlesanox inhibits the phenotype and functional maturation of bone marrow-derived dendritic cells, and is associated with the TBK1 / Akt pathway.
[0041] When using experiments to verify that ammonia can inhibit the phenotype and functional maturation of dendritic cells derived from bone marrow, and that it is related to the TBK1 / Akt pathway, the experimental steps used are as follows:
[0042](1) The femur and tibia bone marrow of female C57BL / 6 mice was cultured under sterile conditions, induced to differentiate with GM-CSF, and immature BMDCs were cultured on the 8th day, and were randomly divided into three groups, among which LPS group was treated with LPS (1 μg / ml) to stimulate BMDC maturation, the ALX group was intervened with different...
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