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A kind of palladium nanoparticles with pei-ciprofloxacin micelles as template and preparation method thereof

A nanotechnology of ciprofloxacin and palladium, which is applied in the field of nanomaterials, can solve the problems of palladium nanoparticles being unstable, prone to coagulation, and affecting catalytic performance, and achieve high stability, high catalytic efficiency, and broad-spectrum antibacterial effect Effect

Active Publication Date: 2020-05-12
河北柏默科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Small-sized palladium nanoparticles exhibit high catalytic activity. However, in the absence of stabilizers and dispersants, palladium nanoparticles are unstable in aqueous solution and prone to coagulation, which affects their catalytic performance.

Method used

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  • A kind of palladium nanoparticles with pei-ciprofloxacin micelles as template and preparation method thereof
  • A kind of palladium nanoparticles with pei-ciprofloxacin micelles as template and preparation method thereof
  • A kind of palladium nanoparticles with pei-ciprofloxacin micelles as template and preparation method thereof

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preparation example Construction

[0037] A preparation method of palladium nanoparticles using PEI-ciprofloxacin micelles as a template, comprising:

[0038] Step S1, prepare PEI-ciprofloxacin complex: mix polyethyleneimine, ciprofloxacin and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, dissolve In an aprotic solvent, hydrochloric acid is added, and after 60-84 hours of reaction, a PEI-ciprofloxacin complex is obtained.

[0039] As a polyelectrolyte dispersant, polyethyleneimine (PEI) can not only stabilize the space through the polymer chain, but also play an electrostatic stabilizing role through its own charge, making the system highly dispersible and stable. Ciprofloxacin is a third-generation quinolone antibacterial drug with broad-spectrum antibacterial activity and good bactericidal effect. The carboxyl group in the ciprofloxacin structure can react with the amino group in the PEI to form an amide bond to obtain a PEI-ciprofloxacin complex (the reaction principle is as follows: figure 1...

Embodiment 1

[0052] The present embodiment provides a kind of palladium nanoparticle with PEI-ciprofloxacin micelles as template, and its preparation method comprises:

[0053] (1) polyethyleneimine (PEI, Mw=600), ciprofloxacin, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl), Dissolve in dimethylsulfoxide (DMSO) at a ratio of 1:1:2, and then add 1M hydrochloric acid (the dosage is one-third of DMSO). The reactant was sonicated for 30 minutes to fully dissolve it, protected in a nitrogen atmosphere for 30-40 minutes, and stirred at room temperature for 72 hours.

[0054] (2) Use a vacuum oven at 85°C to remove the solvent DMSO from the reacted mixture, then dissolve the solid substance removed from the solvent in 4 mL of methanol, dialyze the obtained methanol solution against water for three days, and change it every 8-12 hours water. After the dialysis is completed, the aqueous solution of the obtained product is lyophilized to obtain the pure final product PEI-cip...

Embodiment 2

[0067] The present embodiment provides a kind of palladium nanoparticle with PEI-ciprofloxacin micelles as template, and its preparation method comprises:

[0068] (1) polyethyleneimine (PEI, Mw=600), ciprofloxacin, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl), Dissolve in dimethylsulfoxide (DMSO) at a ratio of 1:1:2, and then add 1M hydrochloric acid (the dosage is one-third of DMSO). The reactant was sonicated for 30 minutes to fully dissolve it, protected in a nitrogen atmosphere for 30-40 minutes, and stirred at room temperature for 72 hours.

[0069] (2) Use a vacuum oven at 85°C to remove the solvent DMSO from the reaction mixture, then dissolve the solvent-removed solid in 4 mL of methanol, dialyze the obtained methanol solution against water for three days, and change the water every 8-12 hours . After the dialysis is completed, the aqueous solution of the obtained product is lyophilized to obtain the pure final product PEI-ciprofloxacin.

[...

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Abstract

The invention provides palladium nanoparticles taking PEI-ciprofloxacin micelle as a template, and a preparation method thereof, and belongs to the field of nanometer material. The preparation methodcomprises following steps: polyethyleneimine, ciprofloxacin, and 1-ethyl-(3-dimethyl amino propyl) carbodiie hydrochlide are mixed, and are dissolved in a non-protonic solvent, hydrochloric acid is added, reaction is carried out for 60 to 84h so as to obtain a PEI-ciprofloxacin compound; the PEI-ciprofloxacin compound is dissolved in an alcoholic solution, an obtained mixed solution is added intowater slowly so as to obtain a PEI-ciprofloxacin micelle solution; and the PEI-ciprofloxacin micelle solution is uniformly mixed with Na2PdCl4, a NaBH4 solution is added, and stirring reaction is carried out for 0.6 to 1.5h at 20 to 30 DEG C. The preparation method is simple, and is convenient to control; the prepared palladium nanoparticles are small in particle size, high in stability, catalyticefficiency, and excellent in antibacterial performance.

Description

technical field [0001] The invention relates to the field of nanomaterials, in particular to a palladium nanoparticle using PEI-ciprofloxacin micelles as a template and a preparation method thereof. Background technique [0002] Due to the outstanding performance of nano-metal particles in the fields of optics, catalysis, electrochemistry, biosensors and antibacterial, more and more people conduct more in-depth research on nano-metal particles. Among them, as a favorable tool for the catalytic reduction of organic pollutant p-nitrophenol, nano-metal particles have attracted extensive attention, because nano-metal particles exhibit more prominent catalytic activity compared with the corresponding large-sized particles. [0003] Small-sized palladium nanoparticles exhibit high catalytic activity. However, in the absence of stabilizers and dispersants, palladium nanoparticles are unstable in aqueous solution and prone to coagulation, which affects their catalytic performance. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J31/28B01J35/08C07C215/76C07C213/02A01N43/60A01P1/00A01P3/00
CPCA01N43/60B01J31/28B01J35/0013B01J35/006B01J35/08B01J2231/641C07C213/02C07C215/76
Inventor 王龙刚张璇赖翔郭全领崔天明
Owner 河北柏默科技有限公司
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