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Probiotic composition and application thereof in improvement of sleep disorder

A technology for improving sleep and composition, applied in the field of probiotics, can solve the problem of lack of effective improvement of sleep disturbance in patients with craniocerebral injury

Pending Publication Date: 2019-10-18
牛占锋
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of this application is to provide an application of a probiotic composition in improving sleep disorders, so as to solve the current problem of lack of effective improvement of sleep disorders in patients with craniocerebral injury

Method used

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  • Probiotic composition and application thereof in improvement of sleep disorder
  • Probiotic composition and application thereof in improvement of sleep disorder
  • Probiotic composition and application thereof in improvement of sleep disorder

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Embodiment Construction

[0013] For patients with craniocerebral trauma, the incidence of gastrointestinal dysfunction is high during treatment. Gastrointestinal function is not only regulated by the brain, but can also react to the brain, and the brain-gut axis is the bridge between the two. The brain-gut axis is a two-way regulatory axis for the interaction between the brain and the gastrointestinal tract, including the central nervous system (CNS), autonomic nervous system (ANS), enteric nervous system (ENS), HPA axis and other structures, and the functions of each part interact with each other. coordination. The gastrointestinal tract is the only organ in the body dominated by the CNS, ANS, and ENS. It has both sensory and motor functions, and is called the "emotional reactor".

[0014] There are a variety of normal microbial communities in the intestinal tract of healthy humans. They have a symbiotic relationship with the host and jointly maintain the physiological balance of the host. Normally...

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Abstract

The invention discloses a probiotic composition which comprises lactobacillus, oribacterium and rothia. The probiotic composition can be administered to regulate the intestinal flora so as to regulatethe sleep disorder of patients with craniocerebral trauma, the significance of the intestinal flora in regulation of the functions and behaviors of brain control is clarified, some theoretical basesare provided for preventing and treating the sleep disorder through intestinal microecological regulation, and the probiotic composition is used for guiding the prevention and treatment of the sleep disorder after clinical craniocerebral trauma.

Description

technical field [0001] The present application relates to the technical field of probiotics, in particular to the application of a probiotic composition in improving sleep disorders. Background technique [0002] Sleep depends on a complex interplay of sleep-wake balance and circadian rhythms in the human body. These rhythmic expressions are largely regulated by the hypothalamic suprachiasmatic nucleus located in the anterior part of the hypothalamus, and are regulated into nearly 24-hour daily rhythms by environmental cues such as light, activity, and diet. The circadian clock genes that regulate the molecular machinery of this circadian rhythm are regulated through self-tuning feedback loop regulation. Bmal1 and CLOCK genes, as the key genes of the circuit, form a heterodimer to regulate the expression of clock-controlled genes, thus driving the output of biological rhythms in the suprachiasmatic nucleus of the hypothalamus. The BMAL1 / CLOCK complex can also activate the ...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P25/20A61P25/00A61K35/741
CPCA61K35/747A61K35/741A61P25/20A61P25/00A61K2300/00
Inventor 牛占锋夏鹤春郝少才
Owner 牛占锋
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