Bionic tendon sheath membrane

A tenosynov membrane and isolation membrane technology, applied in the field of bionic tenosynov membrane, can solve the problem of slow release rate of HA, and achieve the effect of speeding up the healing speed

Active Publication Date: 2019-10-25
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, there is a composite biomimetic membrane (CN201210585375.X a biomimetic tendon sheath membrane and its preparation method) in the actual application process, it is found that the PCL nanofiber membrane loaded with HA has the problem of slow release rate of HA

Method used

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Embodiment Construction

[0029] The present invention will be described in detail below in conjunction with the accompanying drawings.

[0030] The process of preparing fiber film layer 10 and HA composite layer 20 is as follows:

[0031] Step 1, preparing the fiber layer solution: dissolving the degradable polymer material in an organic solvent to form a mixed solution, and controlling the quality of the organic solvent to be 2-50 times the mass of the degradable polymer material;

[0032] Step 2, prepare synovial layer solution: completely dissolve hyaluronic acid or its metal salt in water to make hyaluronic acid or its metal salt gel, control the quality of water to be 10-50 times of the quality of hyaluronic acid; The degradable polymer material is dissolved in an organic solvent to form a mixed solution A, and then hyaluronic acid or its metal salt gel is mixed with the mixed solution A to prepare a synovial layer solution, and the content of the degradable polymer material in the synovial layer...

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Abstract

The invention discloses a bionic tendon sheath membrane which comprises a fiber layer and an HA (hyaluronic acid) compound layer. The bionic tendon sheath membrane is characterized in that four edgesof the fiber layer and the HA compound layer are compounded and bonded, a free bag is placed between the fiber layer and the HA compound layer, the hole diameter of the fiber layer is smaller than that of the HA compound layer, the free bag is prepared by an electrostatic spinning process and comprises a bag body and a plurality of digging ropes, the hole diameter of the bag body is smaller than that of the HA compound layer, the digging ropes are fixed by the free bag extend out of the spaces between the fiber layer and the HA compound layer, the digging ropes can drive the bag body to move to the fiber layer and the HA compound layer between the fiber layer and the HA compound layer when being pulled, the hole diameter of the bag body is larger than the diameter of a hyaluronic acid molecule, gaps are formed in the middle of the HA compound layer, on one hand, hyaluronic acid rapidly flows, on the other hand, the hyaluronic acid is conveniently injected into a bag body, and the freebag is conveniently placed between two membranes. According to the bionic tendon sheath membrane, healing speed of a large-wound tendon is improved, and postoperative effects are improved.

Description

technical field [0001] The invention relates to a bionic tendon sheath, in particular to a bionic tendon sheath used in tendon sheath surgery for isolating the tendon sheath and tissue to prevent adhesion and assist healing. Background technique [0002] The normal tendon sheath is a double membrane-like structure composed of an outer fibrous layer and an inner synovial layer. The fibrous layer is an effective biological barrier to prevent exogenous healing, while the hyaluronic acid-rich synovial fluid secreted by the synovial layer has the function of nourishing the tendon and promoting its sliding. At present, tendon sheath-like tissue has been successfully constructed, and gels and films constructed by HA are also considered as physical barriers with lubricating effect. However, the disadvantage of tenosynovoid tissue is that it cannot secrete synovial fluid, and the physical barrier constructed by hyaluronic acid has a short retention time in the body, poor mechanical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/08A61L27/18A61L27/20A61L27/58
CPCA61F2/08A61L27/18A61L27/20A61L27/58A61L2400/12A61L2430/10A61L2430/34C08L5/08C08L67/04
Inventor 刘珅范存义蔡传栋刘光旺
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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