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Application of polygonum capitatum in regulation of uric acid

A technology of Polygonum vulgare and uric acid, applied in the field of medicine, can solve the problems of never seen hyperuricemia and gout, etc.

Active Publication Date: 2019-10-25
GUIZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report on the treatment of hyperuricemia and gout

Method used

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  • Application of polygonum capitatum in regulation of uric acid
  • Application of polygonum capitatum in regulation of uric acid
  • Application of polygonum capitatum in regulation of uric acid

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Preparation of Polygonum cephalum methanol extract:

[0023] Grind the whole Polygonum cephalosporin, pass through a No. 4 sieve, weigh a certain amount and put it into a round bottom flask, add 8 times the amount of methanol, heat and reflux for extraction for 1 hour, filter, add 8 times the amount of methanol to extract the filter residue for 1 hour, filter, and combine the two The secondary filtrate was concentrated to an extract, and vacuum-dried to obtain a methanol extract of Polygonum cephalosporin with an extraction rate of 13.98%.

Embodiment 2

[0025] Preparation of Polygonum cephalum 80% ethanol extract:

[0026] Grind the whole Polygonum cephalosporin, pass through a No. 4 sieve, weigh a certain amount and put it into a round bottom flask, add 8 times the amount of 80% ethanol-water mixed solvent, heat and reflux for extraction for 1 hour, filter, add 8 times the amount of 80% of the filter residue Extract with ethanol-water mixed solvent for 1 h, filter, combine the two filtrates, concentrate to extract, and vacuum dry to obtain 80% ethanol extract of Polygonum cephalum, with an extraction rate of 21.53%.

Embodiment 3

[0028] Preparation of water extract of Polygonum cephalum:

[0029] Crush the whole Polygonum cephalosporin, pass it through a No. 4 sieve, weigh a certain amount and put it into a round bottom flask, add 8 times the amount of water to soak for 1 hour, decoct and extract for 2 hours, filter, add 8 times the amount of water to extract the filter residue for 1.5 hours, and filter , and then extracted with 8 times the amount of water for 1 h, combined three times the filtrate was concentrated to the extract, and dried in vacuum to obtain the water extract of Polygonum cephalum, with an extraction rate of 20.08%.

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Abstract

The invention relates to the technical field of medicines, in particular to application of polygonum capitatum in regulation of uric acid. Through research, it discovers that the polygonum capitatum can reduce uric acid content in serum of individuals with hyperuricemia by inhibiting the activity of xanthine oxidase in the liver, and can be well applied to regulating uric acid, treating diseases related to hyperuricemia or preparing drugs for treating, preventing, reducing and / or relieving diseases related to hyperuricemia. The polygonum capitatum has effects of resisting hyperuricemia and gout, and a brand-new, safe and effective natural drug for treating the hyperuricemia and the gout is provided.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Polygonum cephalum in regulating uric acid. Background technique [0002] Uric acid is a metabolite of purine compounds in humans. Disorders of purine metabolism or decreased excretion of uric acid in the human body will cause the concentration of uric acid in the blood to continue to increase, resulting in hyperuricemia. Excessive uric acid in the blood will form small needle-shaped monosodium urate (MSU) crystals, which are deposited in joints, kidneys, cartilage, etc., causing non-specific inflammatory reactions in soft tissues, and eventually leading to gout (gout). Therefore, hyperuricemia is the biochemical basis for the induction of gout. [0003] On the other hand, hyperuricemia is also an important factor causing kidney damage, hypertension, hyperlipidemia, atherosclerosis and obesity, and has become one of the major metabolic diseases that threaten...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P19/06
CPCA61K36/704A61P19/06
Inventor 关焕玉廖尚高张春雷李芮马良会何迅廖兴江徐国波周孟董永喜王磊董莉杨小生
Owner GUIZHOU MEDICAL UNIV
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