Bioactive bone repair scaffold and preparation method thereof

A bioactive, bone repair technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problem that cartilage and subchondral bone cannot be repaired together, reduce cartilage degradation damage, excellent mechanical properties controllability, biological The effect of security

Active Publication Date: 2019-10-25
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem: The purpose of the present invention is to provide a bioactive bone repair scaffold and its preparation method. The internal and external structures of the scaffold can be customized, with zero addition of organic solvents, and good multi-component interface bonding, which can meet the mechanical strength requirem

Method used

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  • Bioactive bone repair scaffold and preparation method thereof
  • Bioactive bone repair scaffold and preparation method thereof
  • Bioactive bone repair scaffold and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0041] Example 1

[0042] A biologically active bone repair scaffold, the biologically active bone repair scaffold uses a degradable polymer as a matrix, magnesium lithium silicate and magnesium as reinforcing phases, and includes according to mass percentage:

[0043] Lithium magnesium silicate 5%,

[0044] Magnesium 10%,

[0045] Degradable polymer 85%.

[0046] among them:

[0047] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 85% and a pore diameter of 800 μm.

[0048] The magnesium and magnesium lithium silicate are both granular reinforcing phases, wherein the magnesium lithium silicate is a powder with a particle size of 50-100μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥99.8wt%, in a regular spherical shape with a particle size of less than 40μm .

[0049] The degradable polymer is powdered dextrorotatory polylactic acid PDLA.

[0050] The preparation steps are as follows:

[0051] S1. Pre-gel: Weigh 0.5g of...

Example Embodiment

[0056] Example 2

[0057] A biologically active bone repair scaffold, the biologically active bone repair scaffold uses a degradable polymer as a matrix, magnesium lithium silicate and magnesium as reinforcing phases, and includes according to mass percentage:

[0058] Magnesium lithium silicate 10%,

[0059] Magnesium 20%,

[0060] Degradable polymer 70%.

[0061] among them:

[0062] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 80% and a pore diameter of 700 μm.

[0063] The magnesium and magnesium lithium silicate are both granular reinforcing phases, wherein the magnesium lithium silicate is a powder with a particle size of 50-100μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥99.8wt%, in a regular spherical shape with a particle size of less than 40μm .

[0064] The degradable polymer is powdered polycaprolactone PCL.

[0065] The preparation steps are as follows:

[0066] S1. Pre-gel: Weigh 1.0g lithium magnesiu...

Example Embodiment

[0071] Example 3

[0072] A biologically active bone repair scaffold, the biologically active bone repair scaffold uses a degradable polymer as a matrix, magnesium lithium silicate and magnesium as reinforcing phases, and includes according to mass percentage:

[0073] Lithium magnesium silicate 12%,

[0074] Magnesium 24%

[0075] Degradable polymer 64%.

[0076] among them:

[0077] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 75% and a pore size of 600 μm.

[0078] The magnesium and magnesium lithium silicate are both granular reinforcing phases, wherein the magnesium lithium silicate is a powder with a particle size of 50-100μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥99.8wt%, in a regular spherical shape with a particle size of less than 40μm .

[0079] The degradable polymer is powdered L-polylactic acid PLLA.

[0080] The preparation steps are as follows:

[0081] S1. Pre-gel: Weigh 1.2g lithium magnesium s...

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Abstract

The invention discloses a bioactive bone repair scaffold and a preparation method thereof. The bioactive bone repair scaffold is prepared from, by mass, 55-85% of a degradable polymer serving as a matrix, and 5-15% magnesium lithium silicate and 10-30% of magnesium which serve as a reinforcement phase. The preparation method of the scaffold comprises the following steps of 1) preparation of magnesium lithium silicate hydrogel, 2) preparation of a mixture, 3) preparation of 3D printing raw material particles and 4) 3D printing of the bioactive bone repairing scaffold. The internal and externalstructures of the scaffold can be subjected to customized design, no organic solvent is added, the multi-component interface bonding is good, and the mechanical strength requirement(0.2-80 MPa) of thecancellous bone can be met; self-responding sustained-release of functional ions induces sedimentation of hydroxyapatite on the surface of the scaffold, the bone and cartilage injury can be synergistically repaired, customizedpreparation of the bioactive bone repair scaffold is achieved, and the application prospects of the scaffold in the field of rehabilitation treatment of the bone and cartilage injury and the like are broadened.

Description

technical field [0001] The invention relates to a bioactive bone repair bracket and a preparation method thereof, belonging to the technical field of material preparation. Background technique [0002] Bone grafting scaffolds provide new ideas for joint bone repair and regeneration. About 2.2 million bone scaffolds are used in orthopedic surgery every year in the world, mainly to stimulate new bone formation to replace and regenerate bones caused by joint trauma and disease infection. defect. Orthopedic implant products mainly include spine products, trauma products, artificial bone joint products, etc. At present, joints, trauma and spine are the three mainstream categories of orthopedic medical devices in China. With the advent of aging, bone and joint injury repair will be the fastest growing field in the future. [0003] Articular cartilage injury is one of the most challenging problems in orthopedics and sports medicine given the poor self-healing ability of articular...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/04A61L27/02A61L27/50A61L27/54A61L27/56A61L27/58B33Y10/00B33Y70/00
CPCA61L27/025A61L27/047A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/412A61L2430/06B33Y10/00B33Y70/00C08L67/04
Inventor 白晶周星星董强胜姚庆强张明张惠康程兆俊薛烽
Owner SOUTHEAST UNIV
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