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Preparation method of allopurinol crystal

A technology of allopurinol and crystals, which is applied in the field of preparation of allopurinol crystals, can solve the problems of increasing production safety risks, increasing the pressure of sewage treatment, etc., and achieves the effects of high purity, environmentally friendly auxiliary materials, and simple operation methods

Inactive Publication Date: 2019-10-25
无锡紫杉药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned methods either use acid-base or sulfone solvents, which not only easily increases the risk of production safety, but also increases the pressure of sewage treatment

Method used

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  • Preparation method of allopurinol crystal
  • Preparation method of allopurinol crystal
  • Preparation method of allopurinol crystal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Add 18.0Kg of crude allopurinol to 1080L of purified water, heat to 99°C, stir to dissolve, then add 0.9kg of activated carbon, heat and stir for 30 minutes, then press filter while hot, cool to 20°C, centrifugal filter, wash with 36L of pure water, The solid was dried in a hot air circulation oven at 100° C. for 12 hours to obtain 12.3 kg of allopurinol finished product.

Embodiment 2

[0018] Add 19.6.0Kg of crude allopurinol to 1960L of purified water, heat to 90°C, stir to dissolve, then add 1.9kg of activated carbon, heat and stir for 60 minutes, press filter while hot, cool to 25°C, centrifugal filter, wash with 60L of pure water , the solid was placed in a hot air circulation oven at 105°C and dried for 10 hours to obtain 13.8Kg of allopurinol finished product.

Embodiment 3

[0020] Add 20.5Kg of allopurinol crude product into 1600L of purified water, heat to 95°C, stir to dissolve, then add 1.6kg of activated carbon, heat and stir for 30 minutes, press filter while hot, cool to 30°C, centrifugal filter, wash with 60L of pure water, The solid was dried in a hot air circulation oven at 110° C. for 8 hours to obtain 14.8 Kg of allopurinol finished product.

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Abstract

The invention relates to a preparation method of allopurinol crystal, and belongs to the technical field of bulk pharmaceutical chemical preparation. The preparation method of the allopurinol crystalcomprises the steps that a crude product is added into purified water, stirring and dissolving are carried out under a heating condition, then active carbon is added, filter pressing is carried out during hot after heat-preservation stirring, centrifugal filtration is carried out after cooling, the crude product is washed by the purified water, and drying is carried out to obtain high-purity allopurinol. The operation method is simple, used ingredients are environmentally friendly, the prepared allopurinol has high purity and is suitable for mass production.

Description

technical field [0001] The invention relates to a method for preparing allopurinol crystals, belonging to the technical field of preparation of raw materials. . Background technique [0002] Allopurinol is a classic drug for the treatment of gout. Its preparation method has been explored for decades, and there are already many documents for reference. There are many purification methods for allopurinol, such as in CN 107857764 A, which provides a method for heating and dissolving allopurinol with sodium hydroxide, adding isopropanol, adjusting pH with acetic acid, and finally gradually cooling down to obtain allopurinol; In CN103965197 A, a method for obtaining allopurinol by adding a saturated allopurinol alkaline solution as a raw material, adding a seed crystal, and adding an acidic solution to adjust the pH; as in CN 104447754 A, a method for dissolving allopurinol in a sulfone solvent is provided. Alcohol, add water to get allopurinol crystal method. The above-mentio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/04
CPCC07D487/04C07B2200/13
Inventor 王莉佳黄春陈宏宇葛月兰
Owner 无锡紫杉药业股份有限公司
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