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Application of BEGAIN own antibody detection agent in preparation of lung cancer screening kit

An autoantibody and kit technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of no BEGAIN protein, no lung cancer existing technology, etc., and achieve low patient harm, effective screening, and good application prospects. Effect

Active Publication Date: 2019-11-05
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its relationship with cancer has not been reported yet, and there is no related report on BEGAIN protein autoantibodies, and there is no prior art related to lung cancer

Method used

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  • Application of BEGAIN own antibody detection agent in preparation of lung cancer screening kit
  • Application of BEGAIN own antibody detection agent in preparation of lung cancer screening kit
  • Application of BEGAIN own antibody detection agent in preparation of lung cancer screening kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Relationship Between BEGAIN Autoantibodies in Plasma and Lung Cancer

[0026] 1. Clinical data

[0027] Select 30 cases of lung cancer patients and 30 cases of healthy controls. The basic information is as follows:

[0028] Basic Information lung cancer patients healthy control number of people 30 30 age 58±10.5 42±8.9 male ratio 20(66.7％) 13(46.7％)

[0029] 2. Detection principle

[0030] HuProt TM The BEGAIN protein is immobilized on the human protein custom chip. After incubation with serum, the BEGAIN autoantibodies (mainly including IgG, IgM antibodies, and some other types of antibodies) in the serum will bind to it, and the unbound antibodies and other proteins will be removed by washing. Then use anti-human IgM fluorescently labeled secondary antibody (cy5-labeled, red) and anti-human IgG fluorescent secondary antibody (cy3-labeled, green) to detect, and read the signal through a fluorescent scanner. The streng...

Embodiment 2

[0047] Embodiment 2 The composition of detection kit of the present invention and its using method

[0048] 1. Kit composition

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Abstract

The invention relates to the field of the in vitro diagnostic reagent, and specifically relates to an application of the BEGAIN own antibody detection reagent in the preparation of a lung cancer screening kit. The detection agent disclosed by the invention firstly discovers that the own antibody level of the BEGAIN protein in the lung cancer patient serum is obviously higher than the health patient. The reagent for detecting the BEGAIN protein own antibody is used for preparing the lung cancer screening kit, and the effective screening of the lung cancer can be realized.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular to the use of BEGAIN autoantibody detection reagents in the preparation of lung cancer screening kits. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. Its morbidity and mortality are increasing year by year. Currently, the incidence rate ranks first in the world, which seriously threatens human health and life. [0003] Lung cancer is a disease that is good at concealment. It often shows clinical symptoms when the disease develops to an advanced stage. 70-80% of lung cancer patients are already in the middle or late stage when they are diagnosed with lung cancer symptoms. The best cure time, five-year survival rate is low. For patients with early lung cancer, timely treatment can greatly improve the 5-year survival rate and quality of life of the patients. Therefore, early diagnosis and effective screening of lung cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57423
Inventor 姚梦琳张立
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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