Cherokee rose extract with yang strengthening effect and preparation method and application thereof

A technology of rosacea root and extract, which is applied in the field of rosacea root extract with aphrodisiac effect and its preparation, can solve the problems of incomplete components and low concentration, and achieve the effect of less use, high extraction efficiency and significant therapeutic effect

Inactive Publication Date: 2019-11-08
YULIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to relevant records, it is popular among folks to use golden cherry root stewed chicken as a herbal diet to invigorate the kidney and strengthen yang. However, there is no pharmacological and drug-related research on the activity of golden cherry root for nourishing kidney and strengthening yang.
[0004] Extraction of active components of Rosa japonica mainly adopts water extraction, alcohol extraction, and ultrasonic method, and macroporous resin adsorption method is used for separation of total flavonoids and total saponins. The extracts obtained from these studies have the disadvantages of incomplete components and low concentration.

Method used

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  • Cherokee rose extract with yang strengthening effect and preparation method and application thereof
  • Cherokee rose extract with yang strengthening effect and preparation method and application thereof
  • Cherokee rose extract with yang strengthening effect and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Compound enzyme pretreatment: crush and sieve the root of the golden cherry root to obtain the coarse powder of the golden cherry root, add 20 times the volume of water to the coarse powder of the golden cherry root, stir evenly, add the compound enzyme for enzymolysis, place the mixed solution in an ultrasonic field for treatment, and compound The enzyme composition is cellulase, xylanase, and neutral protease, and the addition amount is 0.6%, 0.2%, and 0.4% of the mass of the root meal of the golden cherry root, the pH value is 6.5, the enzymatic hydrolysis temperature is 50°C, and the ultrasonic power is 400W. The treatment time is 2 hours. After the treatment, the complex enzyme is inactivated at high temperature to obtain the enzymatic hydrolysis solution, which is filtered with a 0.8 μm filter membrane after cooling to obtain the filter residue and filtrate.

[0036] (2) Alcohol precipitation: the filtrate was concentrated to 1 / 4 of the original volume, and 95%...

Embodiment 2

[0042] (1) Compound enzyme pretreatment: crush and sieve the root of the golden cherry root to obtain the coarse powder of the golden cherry root, add 15 times the volume of water to the coarse powder of the golden cherry root, stir evenly, add the compound enzyme for enzymolysis, place the mixed solution in an ultrasonic field for treatment, and compound The enzyme composition is cellulase, xylanase, and neutral protease, and the added amount is 0.6%, 0.3%, and 0.2% of the mass of the root meal of the golden cherry root, the pH value is 5.5, the enzymatic hydrolysis temperature is 60°C, and the ultrasonic power is 250W. The treatment time is 1 hour. After the treatment, the complex enzyme is inactivated at high temperature to obtain the enzymatic hydrolysis solution, which is filtered with a 0.8 μm filter membrane after cooling to obtain the filter residue and filtrate.

[0043] (2) Alcohol precipitation: the filtrate was concentrated to 1 / 4 of the original volume, and 95% eth...

Embodiment 3

[0049] (1) Compound enzyme pretreatment: crush and sieve the root of the golden cherry root to obtain the coarse powder of the golden cherry root, add 10 times the volume of water to the coarse powder of the golden cherry root, stir evenly, add the compound enzyme for enzymolysis, place the mixed solution in an ultrasonic field for treatment, and compound The enzyme composition is cellulase, xylanase, and neutral protease, and the added amount is 0.8%, 0.1%, and 0.6% of the mass of the root meal of the golden cherry root, the pH value is 7.0, the enzymatic hydrolysis temperature is 45°C, and the ultrasonic power is 300W. The treatment time is 3 hours. After the treatment, the compound enzyme is inactivated at high temperature to obtain the enzymatic hydrolysis solution, which is filtered with a 0.8 μm filter membrane after cooling to obtain the filter residue and filtrate.

[0050] (2) Alcohol precipitation: the filtrate was concentrated to 1 / 4 of the original volume, and 95% e...

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Abstract

The invention relates to a cherokee rose root extract with yang strengthening effect and a preparation method and application thereof, and aims to provide a preparation method of the cherokee rose root extract, wherein the method can reduce the residue of impurities in an extracting solution, improve the purity of effective components and improve the safety of a medicinal preparation. The method specifically comprises the following steps of: pre-treating compound enzymes: adding water and the compound enzymes to cherokee rose root crude powder for enzymolysis, wherein the compound enzymes include cellulase, xylanase and neutral protease, and the addition amount is 0.4-0.8%, 0.1-0.3% and 0.2-0.6% of the mass of the cherokee rose root crude powder in sequence; performing ethanol precipitation; performing supercritical CO2 extraction; adding precipitate obtained by the ethanol precipitation into an extractive solution, and performing concentration; performing dissolving with distilled water, performing adsorption with macroporous resin column, and performing gradient eluting with macroporous resin column to obtain eluate; and ultra-filtration: filtering the eluate with an ultra-filtration membrane to obtain the final product. The invention also provides the application of the cherokee rose root extract in a pharmaceutical composition for enhancing male sexual function. The prepared cherokee rose root extract can be used as a medicine for treating impotence and premature ejaculation, and has definite curative effect.

Description

technical field [0001] The invention relates to a preparation method of the extract of the root of the traditional Chinese medicine Rosa chinensis, and more specifically relates to an extract of the root of the rosa chinensis with aphrodisiac effect, its preparation method and application. Background technique [0002] Impotence is the most common male sexual dysfunction disease, also known as erectile dysfunction. It refers to the failure of the penis to achieve or maintain a sufficient erection during sexual life, and fails to complete a satisfactory sexual life, and the course of the disease lasts for more than three months. The main manifestations are slow or difficult erection at the beginning of sexual intercourse; sometimes although erection is erected, the hardness of the erection is not enough, making it difficult or impossible to penetrate the vagina at all. Impotence is usually associated with cardiovascular disease, hyperlipidemia, diabetes, hypothyroidism, andr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61K36/8969A61P15/10A61P15/00A61K35/64
CPCA61K35/64A61K36/232A61K36/296A61K36/355A61K36/39A61K36/43A61K36/484A61K36/537A61K36/638A61K36/64A61K36/704A61K36/738A61K36/815A61K36/8969A61K2236/19A61K2236/331A61K2236/37A61K2236/53A61K2236/55A61P15/00A61P15/10A61K2300/00
Inventor 蒋德旗
Owner YULIN NORMAL UNIVERSITY
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