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Polyinosinic-polycytidylic acid injection and method for lowering toxins in polyinosinic-polycytidylic acid injection

A technology of injection and polymyocytes, which is applied in the field of medicine to achieve the effect of being easy to popularize and use, easy to be safe and effective, and reducing endotoxin

Pending Publication Date: 2019-11-12
CHENGDU HAITONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology combines two methods - one involves injecting certain substances into cells or tissues that have been infected with bacteria called gram negative rods (GNRs) from outside their body's surface while they were still alive but without causing harm themselves. These G NRs act like tiny beads inside another cell where other molecules such as DNA may also enter it through special channels. By combining these techniques together, this process helps reduce the amount of free radical produced during inflammations caused by Gram negatives.

Problems solved by technology

The technical problem addressed in this patented technology relates how to reduce or even eliminate excessive amounts (up to 2000 EUs) of certain chemicals called polysaccharides that are found naturally inside cells during inflammation processes such as virus replication.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The present invention provides a kind of poly muscle cell injection, positive liposome is added in its poly muscle cell injection; The active ingredient is to add positive liposomes in the poly muscle cell injection, and utilize positive liposomes to have a good adjuvant effect, and positive liposomes are liposomes with a positive charge themselves, for Negatively charged liposome delivery carrier, amphiphilic molecules with different chemical structures, at the same time, it has two groups of hydrophilic and hydrophobic, which has the characteristics of good stability in vitro and biodegradability in vivo; positive lipids using this characteristic The plastid is effectively combined with the double-chain polyinosinic acid-polycytidylic acid polymer, which can encapsulate the polymer to form an endocytosis, and then can effectively control the content of endotoxin.

Embodiment 2

[0021] The present invention also provides a method for reducing the endotoxin of polymuscular cell injection, and its specific steps include:

[0022] Dissolving and mixing polyinosinic acid and polycytidylic acid according to a set ratio to form a double-chain polyinosinic acid-polycytidylic acid polymer solution;

[0023] Add positive liposomes to the double-chain polyinosinic acid-polycytidylic acid polymer solution to obtain the liquid to be treated, and magnetically stir the liquid to be treated, of course, other stirring methods can also be selected;

[0024] Then adjust the pH value of the liquid to be treated, and filter the liquid to be treated after adjusting the pH value to obtain the polymuscular cell injection.

Embodiment 3

[0026] In this embodiment, the method for reducing the endotoxin of polymuscular cell injection in embodiment two is further improved and defined, and its specific steps include:

[0027] Dissolving and mixing polyinosinic acid and polycytidylic acid in a ratio of 1:1 to form a double-chain polyinosinic acid-polycytidylic acid polymer solution;

[0028] Add positive liposomes to the double-chain polyinosinic acid-polycytidylic acid polymer solution to obtain the liquid to be treated, and magnetically stir the liquid to be treated to make it evenly stirred;

[0029] Then adjust the pH value of the liquid to be treated, adjust the pH value to 7.0-7.5, and filter the liquid to be treated with a filter with a pore size of 0.45um and / or 0.22um to obtain the polymuscular cell injection.

[0030] Specifically, when using a filter to filter the liquid to be treated, it can be filtered once with a filter with a pore size of 0.45um, and then filtered twice with a filter with a pore size...

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Abstract

The invention discloses a polyinosinic-polycytidylic acid injection and a method for lowering toxins in the polyinosinic-polycytidylic acid injection. Positive lipidosome is added in the polyinosinic-polycytidylic acid injection. The method comprises the steps: polyinosinic acid and polycytidylic acid are dissolved and mixed according to the set proportion, and a double-chain polyinosinic acid-polycytidylic acid polymer solution is formed; the positive lipidosome is added into the double-chain polyinosinic acid-polycytidylic acid polymer solution, thus a to-be-treated solution is obtained, andthe to-be-treated solution is magnetically stirred; and then the PH value of the to-be-treated solution is regulated, the to-be-treated solution subjected to PH value regulating is filtered, and thusthe polyinosinic-polycytidylic acid injection is obtained. According to the polyinosinic-polycytidylic acid injection and the method for lowering the toxins in the polyinosinic-polycytidylic acid injection, the toxins in the polyinosinic-polycytidylic acid injection are effectively lowered, safety and effectiveness of clinical medication are facilitated, and using and popularization are facilitated.

Description

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Claims

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Application Information

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Owner CHENGDU HAITONG PHARMA
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