Composition for repairing hard tissue and kit for repairing hard tissue
A composition and hard tissue technology, applied in tissue regeneration, application, drug delivery, etc., can solve the problems of tissue damage and high fever in the affected area, and achieve the effect of excellent adhesion and excellent invasiveness
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Embodiment 1a～6a
[0166] [Examples 1a to 6a, Comparative Examples 1a to 6a]
[0167] In Examples 1a to 6a and Comparative Examples 1a to 6a, methyl methacrylate as the monomer (A) and polymethyl methacrylate (specific surface area = 0.32 m2) as the spherical polymer powder (b1) were used. 2 / g, Mw=121,000, volume average particle diameter D50=21.9 μ m), polymethyl methacrylate (specific surface area=2.9 μ m) as indeterminate polymer powder (b3) 2 / g, Mw=442,000, volume average particle diameter D50=21.3 μm), as a polymerization initiator (C), a mixture of 85% by mass of tributylboron oxide and 15% by mass of ethanol (manufactured by Mitsui Chemicals Co., Ltd., model BC-Sli) (taking the total of the polymerization initiators (C) as 100% by mass), and barium sulfate (manufactured by Sakai Chemical Industry Co., Ltd.) as a contrast agent (X).
[0168]First, polymer (B) and contrast agent (X) were uniformly dispersed in the mixing ratios shown in Tables 1 and 2 to prepare a mixture. In addition, m...
Embodiment 1b and comparative example 1b
[0179] Except that zirconia (manufactured by High Purity Chemical Laboratories Co., Ltd., trade name Zirconia (IV), and Aldrich Corporation, trade name Zirconium (IV)) with the volume average particle diameter shown in Table 3 was used as the contrast agent (X) Except that instead of barium sulfate, it carried out similarly to Example 4a, the composition for hard tissue repairs was prepared, and it evaluated. The results are shown in Table 3.
[0180] [table 3]
[0181] table 3
[0182]
[0183] As shown in Table 3, the case of changing the contrast agent (X) from barium sulfate to zirconia is also the same, and the hard tissue repair of Example 1b using zirconia with a large volume average particle diameter as the contrast agent (X) The composition has excellent simulated bone penetration and good adhesion to porcine femur bones. On the other hand, the composition for hard tissue repair of Comparative Example 1b using zirconia having a small volume average particle size...
Embodiment 1c～3c
[0184] [Examples 1c to 3c and Comparative Examples 1c to 3c]
[0185] As the polymerization initiator (C), instead of the alkylborane-based polymerization initiator, benzoyl peroxide (manufactured by Aldrich, trade name Luperox (registered trademark) A75) was used in the compounding amount shown in Table 4 and Table 5, 0.5% by mass of N,N-dimethyl-p-toluidine was added to methyl methacrylate as the monomer (A), and the volume average particle diameter of barium sulfate was changed as shown in Tables 4 and 5, except Otherwise, it carried out similarly to Example 4a, the composition for hard tissue repairs was prepared, and it evaluated. The results are shown in Table 4 and Table 5.
[0186] [Table 4]
[0187] Table 4
[0188]
[0189] [table 5]
[0190] table 5
[0191]
[0192] As shown in Tables 4 and 5, when the polymerization initiator (C) is changed from an alkylborane-based polymerization initiator to benzoyl peroxide, the contrast agent (X) with a large volume...
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