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Chip reaction device, manual sample introduction method and applications thereof

A reaction device and manual sampling technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of difficulty in realization, poor fluid controllability, and high machining accuracy requirements, and achieve The effects of saving chip volume, simplifying chip structure, and flexible solutions

Pending Publication Date: 2019-11-19
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, there are certain problems when the above-mentioned technologies are applied to on-site detection.
External mechanical pressure drive and electroosmosis drive often need to provide corresponding auxiliary equipment, which violates the requirements of portability and miniaturization of the equipment; although the micropump drive is small in size, it requires high machining accuracy, is difficult to implement, and the technology is not mature enough; Gravity drive does not require external power, but the controllability of fluid is poor, and it is not suitable for small-scale channels (surface tension is stronger than gravity)

Method used

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  • Chip reaction device, manual sample introduction method and applications thereof
  • Chip reaction device, manual sample introduction method and applications thereof
  • Chip reaction device, manual sample introduction method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Such as figure 1 As shown, the chip reaction device includes a manual sampler 1 and a chip 2;

[0068] figure 1 Middle g shows the structure of the chip 2, the chip 2 is a circular scattering multi-channel chip, including 1 sample inlet 23 and 6 reaction pools 22 equidistant from the sample inlet 23, 6 flow channels Road 21 communicates with each reaction pool 22 and sample inlet 23 respectively; figure 1 In a-d, only the sample inlet 23 of the chip 2 is shown, and in e-f, only a group of flow channels 21 and the reaction pool 22 of the chip 2 are shown;

[0069]Described manual sample injector 1 comprises the cylindrical sample cuvette 12 of polyethylene system, cup-shaped control part 11 and sample discharge part 13, and described control part 11 is arranged on the inside of described sample cuvette 12, and described The sample pool 12 is detachably sealed and connected to allow the sample to enter and remain in the sample pool 12 or to push the sample out of the s...

Embodiment 2

[0073] Such as figure 2 As shown, the chip reaction device includes a manual sampler 1 and a chip 2;

[0074] The structure of the chip 2 is the same as in Embodiment 1, figure 2 h shows the structure of chip 2, d-e shows only the sample inlet 23 of chip 2, f-g shows only a group of flow channels 21 and reaction pool 22 of chip 2, a-c shows manual sample injection The sample loading process of device 1;

[0075] Described manual sample injector 1 comprises the tubular sample cell 12 of polyethylene system, the cylindrical control part 11 that is connected with it and sample outlet 13, and described control part 11 is connected with the top of described sample cell 12, uses In order to make the sample enter and hold in the sample cell 12 or to push the sample out of the sample cell 12 through the sample outlet part 13, the control part includes a flexible side wall with variable height as its deformable part, the The deformation control of the stretchable side wall can cha...

Embodiment 3

[0079] Such as image 3 As shown, the chip reaction device includes a manual sampler 1 and a chip 2;

[0080] image 3 Middle h shows the structure of the chip 2, the chip 2 is a parallel multi-channel rectangular chip, including three groups of five reaction pools 22 connected in series through the flow channels 21, and each group of reaction pools passes through the flow channels 21 and enters the The sample port 23 is connected; image 3 In d-e, only the sample inlet 23 of the chip 2 is shown, in f-g, only a set of flow channels 21 and the reaction pool 22 of the chip 2 are shown, and in a-c, the sample loading process of the manual injector 1 is shown;

[0081] The manual sample injector 1 comprises a cylindrical sample pool 12 made of polyethylene, a cylindrical control part 11 connected with a piston, and a sample outlet 13, and the control part 11 is connected with the sample pool 12 for making The sample enters and remains in the sample pool 12 or the sample is push...

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Abstract

The invention relates to the field of micro total chips, and discloses a chip reaction device, a manual sample introduction method and applications thereof. The chip reaction device includes a manualsample introduction device and a chip. The chip includes a flow channel, a reaction tank and a sample introduction port and communicates with the reaction tank and the sample introduction port throughthe flow channel. The manual sample introduction device includes a sample cell, a control section and a sample outlet section. The control section is connected to the sample cell and is used for allowing samples to enter and be held in the sample cells or allowing the samples to be pushed out of the sample cell through the sample outlet section. The sample outlet section is located at one side, being opposite to the control section, of the sample cell. The manual sample introduction section is connected to the sample introduction port in a sealing manner. The chip reaction device of the invention can accurately control the flow mode of the samples, and can manually realize multiple functions such as sampling, mixing and driving, which simplified the device and helps to provide the controllability and repeatability of operation.

Description

technical field [0001] The invention relates to the field of micro-full chips, in particular to a chip reaction device, a manual sampling method and an application thereof. Background technique [0002] One of the development directions of modern instruments is miniaturization, integration and portability. No matter in the field of life science, chemical engineering, or environmental protection, the emergence of micro total analysis system (microTAS) has brought about revolutionary changes. The purpose of micro-total analysis is to integrate functions, integrating complex functions such as sample preparation, separation, purification, reaction, and monitoring that originally needed to be realized in the laboratory into micro-analysis equipment or even credit card-sized chips, so it is also called " Lab on a Chip". [0003] Micro-total analysis technology was proposed by Manz in the 1990s. Thanks to the development of micro-electromechanical processing, biochemistry and oth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L2300/0867B01L2300/12B01L2200/0642B01L2200/0689
Inventor 孙冰王林姜慧芸姜杰文松石宁
Owner CHINA PETROLEUM & CHEM CORP
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