Synergy effect of cobra neurotoxin polypeptide on hyperalgesia and tolerance and alleviating pain of opioids

Abstract

An opioid receptor agonist is a powerful effect analgesic medicine which is clinically and widely used, morphine is representative, and the medicine can effectively relieve pain of patients, particularly for pain of people after an operation and in the terminal cancer. However, opioids are easy to cause tolerance and hyperalgesia of patients, and the tolerance and the hyperalgesia can be easily formed within one week. Once the tolerance and the hyperalgesia are formed, dosage is continuously increased to continue to maintain the effect of alleviating pain, namely that organisms need a massivedose of medicines to achieve the effect of alleviating pain as the initial dose, but the higher dose can cause serious hyperalgesia, tolerance, constipation, addiction and respiratory depression. Cobra neurotoxin polypeptide can restrain the hyperalgesia and the tolerance of the opioids, and can also improve the treatment effects of opioids, and when the cobra neurotoxin polypeptide and the opioids are combined together for use, the opioids can alleviate pain at the lower dose and does not generate tolerance and hyperalgesia, so that the clinical technical problem that the opiods cannot be used for a long term can be solved.

Description

Technical field: [0001] The invention belongs to the field of biopharmaceuticals, and relates to the new clinical application of cobra neurotoxin, specifically, to the clinical application of suppressing the side effects of opioid drugs and synergizing the analgesic effect of opioid drugs. Background technique: [0002] Opioids are substances extracted from the poppy plant. They bind to the body's own opioid receptors and, when legally prescribed, provide pain relief or analgesia to patients with acute or chronic pain; morphine is an example of an opioid analgesic. The short-term use of these drugs is considered a safe method of pain management, however, when they are overused and / or used regularly they can produce a range of problems including pain hypersensitivity, intolerance, drug dependence, constipation, respiratory depression and fatal overdose. Opioid overdoses killed more than 33,000 people in 2015, according to the U.S. Centers for Disease Control and Prevention....

AI Technical Summary

Problems solved by technology

Although the combination of opioids and other drugs has become an effective strategy to enhance the analgesic effect of opioids and suppress analgesic tolerance and hyperalgesia, there is no drug with definite curative effect that can be used. Products that can really satisfy doctors and patients

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