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Application of TNF alpha micromolecule inhibitor C87 to preparation of medicines for treating glioma

A technology of small molecule inhibitor and α inhibitor, applied in the field of TNFα inhibitor, can solve the problems of unknown cause and poor reactivity, etc.

Active Publication Date: 2019-12-03
INST OF HEMATOLOGY & BLOOD DISEASES HOSPITAL CHINESE ACADEMY OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE +1
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Problems solved by technology

This drug resistance is different from the secondary drug resistance caused by long-term use of the same EGFR inhibitor in patients with non-small cell lung cancer. Mechanisms of this resistance are poorly studied and reasons are unknown

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  • Application of TNF alpha micromolecule inhibitor C87 to preparation of medicines for treating glioma
  • Application of TNF alpha micromolecule inhibitor C87 to preparation of medicines for treating glioma
  • Application of TNF alpha micromolecule inhibitor C87 to preparation of medicines for treating glioma

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Embodiment Construction

[0024] In order to better understand the present invention, the present invention will be described in detail below in conjunction with specific drawings.

[0025] 1. Experimental method

[0026] 1.1 Experimental materials:

[0027] Human glioblastoma cell lines U87 and LN229 were purchased from ATCC cell bank in the United States. Fifteen cases of low-grade astrocytoma tissues and 16 cases of glioblastoma tissues were obtained from newly diagnosed glioma patients with definite pathological diagnosis after surgery from June 2014 to June 2016 in the Brain Oncology Department of our hospital. All subjects signed informed consent, and this study was approved by the Ethics Committee of Tianjin Medical University Cancer Hospital. EGFR vⅢ virus was purchased from Jikai Genomics Co., Ltd., infected U87 and LN229 cell lines according to the instructions, and was stably screened for two weeks before use. Gefitinib was purchased from Selleck, C87 was purchased from Tocris and Specs, ...

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Abstract

The invention provides an application of a TNF alpha micromolecule inhibitor C87 to preparation of medicines for treating glioma. The research confirms that TNF alpha in microenvironment can initiatereverse tolerance of glioblastoma cells to EGFR inhibitors by activating downstream JNK kinase and Axl kinase, and the TNF alpha specificity micromolecule inhibitor C87 can notably improve the treatment sensibility of the glioblastoma cells to the EGFR inhibitors. Relevant research results are not only important supplements for enabling inflammatory factors using TNF alpha as representative and brain tumors to generate relationship, but also provide a new treatment strategy and standby medicines for patients suffering from glioma at the late period. The TNF alpha micromolecule inhibitor C87 has favorable clinical application prospects and potential economic benefits.

Description

technical field [0001] The invention relates to a new application of TNFα inhibitors, in particular to the application of TNFα small molecule inhibitor C87 in the preparation of medicaments for treating brain glioma. Background technique [0002] Glioma is the most common tumor of the central nervous system. It grows aggressively and has no clear boundary with normal brain tissue. It is difficult to completely remove it. It is not very sensitive to radiotherapy and chemotherapy, and it is very easy to relapse. It grows in important parts such as the brain. Malignant tumors that are difficult to remove or inoperable at all. Chemical drugs and general anti-tumor traditional Chinese medicines have unsatisfactory curative effects due to the influence of blood-brain barrier and other factors. Therefore, glioma is still one of the tumors with the worst prognosis among systemic tumors. [1] . Glioblastoma (glioblastoma) is a WHO grade IV glioma, which is different from other low-g...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61K31/5377A61P35/00
CPCA61K31/427A61K31/5377A61P35/00A61K2300/00
Inventor 许元富李文良马莉
Owner INST OF HEMATOLOGY & BLOOD DISEASES HOSPITAL CHINESE ACADEMY OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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