Preparation method of magnetic nanoparticles with improved dispersion and particle uniformity

A technology of magnetic nanoparticles and uniform particles, which can be used in medical preparations with non-active ingredients, medical preparations containing active ingredients, nanotechnology for materials and surface science, etc., and can solve the problem of weakening the agglomeration effect of nanoparticles In order to prevent problems such as agglomeration, achieve good dispersion, prevent mutual agglomeration, improve dispersion and uniformity

Active Publication Date: 2021-10-15
NANJING XIAOZHUANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the surface coating modification method is used to coat the surface of nanoparticles, the agglomeration effect of nanoparticles is weakened; but the coating produces steric repulsion, which is not enough to prevent the agglomeration

Method used

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  • Preparation method of magnetic nanoparticles with improved dispersion and particle uniformity
  • Preparation method of magnetic nanoparticles with improved dispersion and particle uniformity
  • Preparation method of magnetic nanoparticles with improved dispersion and particle uniformity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of FE covering mesoporous silica 3 O 4 Nanoparticles

[0039]Put 10-15 nm Fe 3 O 4 Nanoparticles were dispersed in an aqueous solution of 0.1 wt% hydroxyethylcellulose at 100 ml of 50 ° C, and tetraeth escetate 10 ml of n-silicate, 25 ml of ethyl acetate was added, stirred for 10 min, and then dissolved for 10 min. - Aminopropyl-triethoxysilane 1.5 mL, maintaining the reaction liquid temperature of 65 ° C, stirring reaction for 24 hours, cooled, centrifuged, 6 times with ethanol, to obtain a surface covering mesoporous silica 3 O 4 Nanoparticles are split in water.

Embodiment 2

[0041] Silica-FE3O4 nano-core particles for preparing surface modified photosensitizers

[0042] Under the prevention of light, a 5.4 g of a hematoporphoporphoporphin-sensitive agent was dissolved in 100 mL DMF, weighted 4.2 g of EDC in 100 mLDMF, weighing 7.2 g of NHS dissolved in 100 ml DMF, combined with the above DMF solution, and activated at room temperature 4. In the animation, 2.5 g of methylpropylpropyltrimethoxysilane and 6 mmol of 6 mmol were dispersed in the solution were added to the surface of the surface of the above-described surface coating. 3 O 4 Nanoparticles, the dispersion solution is 0.1 wt% hydroxyethylcellulose aqueous solution; oscillating reaction overnight, dispersion, deionized water washing, dry, to obtain a mesoporous silica surface modified photosensitive Fe 3 O 4 Nanoparticles.

Embodiment 3

[0044] Magnetic nanoparticles with improved dispersibility

[0045] 3-5 nm nano gold particles were dispersed in 20 ml of DMF, weighted 1.2 g of EDC dissolved in 40 ml of DMF, weighed 2.0 g of NHS dissolved in 40 ml of DMF, combined with the above DMF solution, and activated at room temperature for 4 hours, activated The formation of a mesoporous silica surface modified photosensitive agent 3 O 4 The PVA / PVP composite dispersion of nanoparticles, wherein the PVA concentration in the dispersion is 0.2% by weight, the PVP concentration is 0.05 wt%; the oscillating reaction is overnight, dispersion is discarded, and the deionized water is cleaned, and ultrasonic dispersion in deionized water 15min, centrifugation, magnetic nanoparticles.

[0046] The prepared magnetic nanoparticles were characterized by TEM. From figure 2 The characterization results show that the prepared nanoparticles have a significant nuclear shell structure, the particles are spherical, the particle size is 50...

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Abstract

The invention relates to a method for preparing magnetic nanoparticles with improved dispersibility and particle uniformity. The method comprises the following steps: preparing Fe coated with mesoporous silica 3 o 4 Nanoparticles; Silica‑Fe for Preparation of Surface Modified Photosensitizers 3 o 4 Nanocore particles; preparation of magnetic nanoparticles with improved dispersibility. The method of the present invention utilizes the method of combining macromolecular polymerization inhibitor and ultrasonic dispersion to effectively prevent the mutual agglomeration of nanoparticles, thereby preparing magnetic nanoparticles with good dispersibility.

Description

Technical field [0001] The present invention belongs to the field of magnetic resonance nanomaterials, and in particular, the present invention relates to a method for preparing a magnetic nanoparticle for magnetic resonance imaging. Background technique [0002] In 1973, Lauterbur first applied magnetic resonance imaging, MRI to human body diagnosis, and this technology has been rapidly developed and widely used in the fields of biological, medical. MRI has been widely used in the body's head, nervous system, abdominal and blood vessels, which is particularly effective for detecting tissue necrosis, local ischemia and various malignant lesions, and early diagnosis, and monitoring the metabolism of human cycle systems. [0003] Magnetic nanomaterials have broad applications due to their unique magnetic properties of nanometer scale, have been used in many ways such as magnetic records, magnetic probes. In recent years, the application of magnetic nanoparticles has been extended t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/18A61K47/69A61K41/00A61P35/00B82Y5/00B82Y20/00B82Y25/00B82Y30/00B82Y40/00
CPCA61K41/0071A61K49/1854A61K47/6923A61P35/00B82Y5/00B82Y20/00B82Y25/00B82Y30/00B82Y40/00
Inventor 唐宁张边江陈全战
Owner NANJING XIAOZHUANG UNIV
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