Whitening composition and method for preparing microemulsion type cosmetics

A technology of composition and cosmetics, which is applied in the field of preparation of whitening composition and its microemulsion composition, can solve the problems of not being able to quickly exert the beauty care function and difficult to penetrate the skin barrier, and achieve the goal of increasing bioavailability and promoting absorption Effect

Pending Publication Date: 2019-12-27
QINGDAO YOUDO BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Tranexamic acid is a plasminogen activator inhibitor. Its chemical structure is similar to tyrosine. It can compete with tyrosinase to inactivate tyrosinase. It can also inhibit inflammation and inhibit UV Inflammation after irradiation, but it is difficult to penetrate the skin barrier and cannot quickly exert effective beauty care functions

Method used

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  • Whitening composition and method for preparing microemulsion type cosmetics
  • Whitening composition and method for preparing microemulsion type cosmetics
  • Whitening composition and method for preparing microemulsion type cosmetics

Examples

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Effect test

preparation example Construction

[0042] 1. Preparation of microemulsion cosmetics

[0043] 1.1 Preparation method of glabridin inclusion compound

[0044] Weigh hydroxypropyl β-cyclodextrin according to the amount, add distilled water, stir and dissolve with a magnetic stirrer;

[0045] Dissolve glabridin in a small amount of absolute ethanol, add dropwise to the hydroxypropyl β-cyclodextrin solution, and continue stirring at 42°C for 2 hours to obtain the clathrate;

[0046] Suction-filter the inclusion compound, put the filtrate in the refrigerator for 24 hours, freeze-dry in vacuum for 24 hours to obtain the inclusion compound of glabridin.

[0047] 1.2 Glabridin inclusion compound

[0048] Inclusion compound 1: Weigh 10 parts of hydroxypropyl β-cyclodextrin by weight, add 88 parts of distilled water, stir and dissolve with a magnetic stirrer; dissolve 1 part of glabridin with 1 part of absolute ethanol, add hydroxypropyl In the base β-cyclodextrin solution, continue to stir at 42°C for 2 hours to obtai...

Embodiment 1

[0054] Embodiment 1: In parts by weight, 1 part of whitening composition is mixed with 1 part of isopropyl myristate to obtain the first oil phase; the first oil phase is mixed with 2 parts of surface agent (Tween80:Span80=1: 1) Mix to obtain the second mixed oil phase; 1 part of co-surfactant propylene glycol, 0.1 part of sodium hyaluronate, 2 parts of Luba gum, 1 part of purslane extract, 1 part of carnosine and 90.9 parts of water phase are mixed to form The first mixed water phase; add the first mixed water phase to the second mixed oil phase, and stir evenly at room temperature to obtain a microemulsion cosmetic.

Embodiment 2

[0055]Embodiment 2: In parts by weight, 5 parts of whitening compositions are mixed with 5 parts of isopropyl myristate to obtain the first oil phase; the first oil phase is mixed with 10 parts of surface agent (Tween80:Span80=1: 1) Mix to obtain the second mixed oil phase; 10 parts of co-surfactant propylene glycol, 0.1 part of sodium hyaluronate, 2 parts of Luba gum, 1 part of purslane extract, 1 part of carnosine and 65.9 parts of water phase are mixed to form The first mixed water phase; add the first mixed water phase to the second mixed oil phase, and stir evenly at room temperature to obtain a microemulsion cosmetic.

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Abstract

The invention discloses a whitening composition, a microemulsion type composition and preparation method. The whitening composition comprises a Glabridin inclusion compound, nicotinamide and tranexamic acid which are in a weight ratio of (1 to 5): (1 to 5): (1 to 5); and the Glabridin inclusion compound is prepared from Glabridin and hydroxypropyl beta-cyclodextrin which are in a weight ratio of (1 to 10): (1 to 40). Microemulsion type cosmetics are prepared through firstly enveloping the Glabridin and then, preparing a microemulsion from the enveloped Glabridin, the nicotinamide and the tranexamic acid. Active matters are protected to be transported to deep layers of skin, the activity of the Glabridin is guaranteed, the absorption to the whitening composition is promoted, and the bioavailability is improved.

Description

technical field [0001] The invention relates to a cosmetic composition, in particular to a whitening composition and a preparation method for a microemulsion composition thereof. Background technique [0002] Skin melanocytes are mainly distributed in the basal layer. There are three main enzymes that regulate melanin synthesis: tyrosinase, dopachrome interconversion enzyme, and dihydroxyindole carboxylic acid oxidase. Tyrosinase is a biological The key enzyme and rate-limiting enzyme for the synthesis of melanin in the body. Melanosomes are located in the cytoplasm of melanocytes. Melanosomes are first transferred to the distal dendrites, and then transported from melanocytes to keratinocytes. [0003] Commercially available whitening agents have various problems, such as kojic acid has liver toxicity, hydroquinone has cytotoxicity, etc. Commercially available whitening products usually add a large amount of keratin exfoliants and whitening ingredients in order to pursue a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/49A61K8/44A61K8/06A61Q19/02
CPCA61K8/675A61K8/44A61K8/498A61K8/068A61Q19/02A61K2800/56A61K2800/84
Inventor 贾凯李生慧于钰丁松李军
Owner QINGDAO YOUDO BIOENG
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