Application of Xiqingguo polyphenols in the preparation of drugs for the treatment of methamphetamine addiction
A methamphetamine and drug technology, which is applied in the field of preparation of drugs for the treatment of methamphetamine addiction, and can solve problems such as methamphetamine relapse
Active Publication Date: 2021-07-13
JIANGHAN UNIVERSITY
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Problems solved by technology
[0004] Aiming at the problem of methamphetamine relapse, the invention provides the application of green fruit polyphenols in the preparation of anti-methamphetamine addiction drugs
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[0019] Materials and Methods:
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The invention discloses the application of prunus polyphenols in the preparation of drugs for treating methamphetamine addiction, and evaluates the effect of prunus polyphenols on the prevention and treatment of methamphetamine by investigating the influence of prunus polyphenols on methamphetamine-induced behavioral sensitization The role in addiction. It has been proved by experiments that the polyphenols of prunes can effectively weaken the dependence and craving for methamphetamine, weaken the behavioral sensitization effect induced by methamphetamine, and can treat methamphetamine addiction. It has a good clinical application prospect.
Description
technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the medical use of anti-oxidant prunus polyphenols, which can be used to prepare medicines for treating methamphetamine addiction. Background technique [0002] Methamphetamine (METH) is an amphetamine-type psychostimulant. After application, it will increase the level of dopamine (DA) in the central nervous system and produce a strong euphoric effect. It is a synthetic drug. Different from the main sedative and analgesic effects of traditional drugs, METH has two main characteristics of mental dependence and neurotoxicity, and can induce nerve damage in a short time after ingestion. Long-term abuse of METH can promote mental illness and aggressive behavior in addicts, and cause neuron damage and nuclei atrophy in the prefrontal cortex, hippocampus, and striatum of the abuser, which is related to changes in brain functions, such as emotional recognition It is close...
Claims
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IPC IPC(8): A61K36/185A61P25/36
CPCA61K36/185A61P25/36
Inventor 马宝苗乐凯林款龚晓康皮明山田香茹琴
Owner JIANGHAN UNIVERSITY