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Application of pyrazolopyrimidine derivative in treating chronic pelvic inflammatory disease

A technology for pyrazolopyrimidine and chronic pelvic inflammatory disease, applied in the field of pyrazolopyrimidine derivatives for the treatment of chronic pelvic inflammatory disease, can solve problems such as the use of chronic pelvic inflammatory disease, expand drug selectivity, expand application range, The effect of multiple drug choices

Active Publication Date: 2020-02-25
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are only reports about pyrazolopyrimidine derivatives in the treatment of acute myeloid leukemia and psoriasis, but no use in the treatment of chronic pelvic inflammatory disease

Method used

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  • Application of pyrazolopyrimidine derivative in treating chronic pelvic inflammatory disease
  • Application of pyrazolopyrimidine derivative in treating chronic pelvic inflammatory disease
  • Application of pyrazolopyrimidine derivative in treating chronic pelvic inflammatory disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The effect research of embodiment 1 to chronic pelvic inflammatory disease model rat

[0030] 1. Experimental animals: 90 SPF-grade female SD rats, body weight (200±20) g, provided by the Experimental Animal Center of Sichuan University.

[0031] 2. Experimental materials: pyrazolopyrimidine derivatives were synthesized by the inventors. Mix castor oil and ethanol 1:1 and pass through a 0.22 μm sterile filter membrane to obtain ELE solution, weigh a certain amount of pyrazolopyrimidine derivative powder of the present invention, dissolve the powder with ELE solution, and after the powder is completely dissolved, Add a certain volume of sterilized water, mix well and set aside. The volume ratio of ELE solution to sterile water is 1:3. Escherichia coli and Staphylococcus aureus were provided by the Department of Microbial Immunology, Guangxi University of Traditional Chinese Medicine. According to the ratio of Escherichia coli: Staphylococcus aureus = 1:1, the density ...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of a pyrazolopyrimidine derivative in treating chronic pelvic inflammatory disease. The chronic pelvic inflammatory disease is related to increase of blood viscosity in inflammatory tissue and enhancement of expression of ICAM-1 and FGF-2. The pyrazolopyrimidine derivative disclosed by the invention can generate the good treatment effect on chronic pelvic inflammatory disease by reducing blood viscosity, and inhibiting ICAM-1 and FGF-expression in tissues and other combined action mechanisms.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the use of pyrazolopyrimidine derivatives in treating chronic pelvic inflammatory disease. Background technique [0002] Chronic pelvic inflammatory disease (CPID) refers to a series of sequelae caused by pelvic inflammatory diseases that have not been treated in time and correctly, mainly manifested as recurrent pelvic pain, lumbosacral pain, and dysmenorrhea, which can easily lead to infertility, ectopic pregnancy, etc. . The main pathological changes of CPID are mostly local inflammatory exudation, adhesion, and hyperplasia in the pelvic cavity. Unlike PID, which is mainly caused by bacterial infection, antimicrobial therapy is better for the acute phase, but not for CPID. [0003] The pyrazolopyrimidine derivative (Formula I) is a small-molecule inhibitor targeting FLT3 kinase. It is a new type of compound independently developed by the applicant. At present, the compound ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P15/00
CPCA61K31/519A61P15/00
Inventor 钟杰敏赖树生巫鑫聂雪玫陈丹覃秋琳
Owner GUANGXI WUZHOU PHARMA GRP
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