A kind of polydopamine film and its preparation method and application

一种聚多巴胺薄膜、反应的技术，应用在医用植入材料中的应用领域，能够解决腐蚀性、解聚和溶膜现象、负载难题等问题，达到提高安全性能、避免腐蚀作用、避免刺激和腐蚀的效果

Active Publication Date: 2022-04-12
B J ZH F PANTHER MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ammonia solution of sulfadiazine silver is corrosive to the polydopamine film, especially ammonia water can cause the depolymerization and film dissolution of the polydopamine film; further, the catalyst trifluoromethanesulfonic acid or trifluoromethanesulfonate will There is a certain amount of attachment and binding on the polydopamine film, and it competes with silver sulfadiazine for the attachment site, and trifluoromethanesulfonic acid or trifluoromethanesulfonate also has certain toxicity, so it is not suitable for the field of medical devices; the above Reasons that make the loading of silver sulfadiazine on the surface of biomedical implant materials a problem

Method used

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  • A kind of polydopamine film and its preparation method and application
  • A kind of polydopamine film and its preparation method and application
  • A kind of polydopamine film and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] 1. Preparation of polydopamine coating:

[0058] 1.1 The cleaned pure titanium medical implant material is irradiated with ultraviolet rays for 1 hour, then soaked in Tris-HCL solution containing 2g / L dopamine monomer at pH 8.5, and then calcium peroxide with a final concentration of 10mg / L is added. Immediately put the reaction bottle containing the mixture into the body cavity of a temperature-controllable focusing microwave synthesizer, and react at a constant temperature of 25°C for 3 minutes, with a microwave power of 300W, and a dense polydopamine film can be obtained on the surface of the implant. Take it out and wash it repeatedly by ultrasonic, rinse it with deionized water, and dry it with nitrogen gas.

[0059] 1.2 does not repeat 1.1. The polydopamine film is a single layer.

[0060] 2. In Situ Synthesis of Silver Sulfadiazine on Conventional Polydopamine Films

[0061] 2.1 Put the material treated in 1.2 in a solution of sulfadiazine (20mmol / L) in sodium...

Embodiment 2

[0064] 1. Preparation of polydopamine coating:

[0065] 1.1 Irradiate the cleaned titanium alloy (TI-6AL-4V) medical implant material under ultraviolet light for 6 hours, then soak it in a pH7.1 Tri-HCL solution containing 1g / L dopamine monomer, and then add a final concentration of 20mg / L of calcium peroxide, immediately put the reaction bottle containing the mixture into the body cavity of the temperature-controllable focusing microwave synthesizer, react at a constant temperature of 65°C for 5 minutes, and the microwave power is 100W, and a A dense polydopamine film was taken out, washed repeatedly by ultrasonic waves, rinsed with deionized water, and dried with nitrogen.

[0066] 1.2 Repeat step 1.1 4 times. The final polydopamine film is 5 layers.

[0067] 2. In Situ Synthesis of Silver Sulfadiazine on Conventional Polydopamine Films

[0068] 2.1 Place the material treated in 1.2 in a solution of sulfadiazine (30mmol / L) in sodium hydroxide (45mmol / L), pH 8.7, so that ...

Embodiment 3

[0071] 1. Preparation of polydopamine coating:

[0072] 1.1 The cleaned titanium alloy (Ti-25nb-10ta-1zr-0.2fe) medical implant material was irradiated under ultraviolet light for 12 hours, and then soaked in a pH8.0 Tri-HCL solution containing 3g / L dopamine monomer, Calcium peroxide with a final concentration of 40 mg / L was then added, and the reaction bottle containing the mixture was immediately put into the body cavity of a temperature-controllable focusing microwave synthesizer, and reacted at a constant temperature of 50°C for 11 minutes, and the microwave power was 100W, and the plant was ready. A dense polydopamine film was obtained on the surface of the object, which was taken out and washed repeatedly with ultrasonic waves, rinsed with deionized water, and dried with nitrogen gas.

[0073] 1.2 Repeat step 1.1 9 times. The polydopamine film is 10 layers.

[0074]2. In Situ Synthesis of Silver Sulfadiazine on Conventional Polydopamine Films

[0075] 2.1 Put the mate...

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Abstract

The invention discloses a polydopamine film, a preparation method and application thereof. The polydopamine film is loaded with silver sulfadiazine, and the preparation method realizes the in-situ synthesis of silver sulfadiazine on the conventional polydopamine film through microwave irradiation. In this method, traditional ammonia solution is not used to dissolve sulfadiazine, which has the following advantages: first, it can avoid the corrosion effect of ammonia solution on polydopamine film; second, it can avoid the stimulation and corrosion of ammonia solution on mucous membranes such as eyes and nasal cavities of workers; Third, it can avoid environmental problems caused by the irritating smell and smog volatilized by high-concentration ammonia water. In this method, the loading capacity of silver sulfadiazine can be increased and the safety performance can be further improved without using catalyst trifluoromethanesulfonic acid or trifluoromethanesulfonate.

Description

technical field [0001] The present invention relates to a polydopamine film and its preparation method and application, in particular to a polydopamine film loaded with silver sulfadiazine, which is prepared by synthesizing silver sulfadiazine in situ on a conventional polydopamine film by microwave irradiation The film method and the application of the polydopamine film in medical implant materials. Background technique [0002] At present, when biomedical implant materials are implanted in surgical operations, the possible infection is still a very difficult clinical problem. Although biomedical implant materials such as inorganic materials, organic materials and metals and their alloys (such as: ceramics, polymer materials, stainless steel, pure titanium and its alloys, and pure magnesium and its alloys, etc.), due to their excellent mechanical properties and Good biocompatibility has been widely used in the repair of hard and soft tissues, but these implant materials th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/08A61L31/16
CPCA61L31/10A61L31/16A61L2300/104A61L2300/404C08J7/065C07D239/42A61L31/14C08J2379/04C08L79/02A61B17/11A61B2017/00893A61B2017/0647A61L2420/02B05D1/18B05D3/06C08J5/18C08J2379/02C08K5/3462
Inventor 刘青蒲丛
Owner B J ZH F PANTHER MEDICAL EQUIP
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