Personalized coronary stents

Abstract

A method includes the steps: generating a 3-D model of an unstenosed geometry of a blood vessel responsive to a 3-D model of an actual geometry of the blood vessel, establishing a parametric description of a stent that is expanded from a collapsed configuration to a final configuration that apposes the unstenosed geometry, developing a design for the stent by varying parameters of the parametric description responsive to a design heuristic that includes risk of stent strut breakage during a plastic deformation between the collapsed configuration and the final configuration, embodying the stentaccording to the design for the stent, inserting the stent info a blood vessel in its collapsed configuration, maneuvering the stent through the blood vessel to a stenosis, and expanding the stent toits final configuration.

Description

technical field [0001] The present invention relates to the field of medicine, and more particularly to interventional cardiology. Background technique [0002] Cardiovascular disease is one of the largest health problems in developed countries. One of the more serious forms is coronary artery disease (CAD), in which part of the smooth, elastic lining inside the coronary arteries usually hardens, hardens and swells, with calcium deposits, fatty deposits and abnormal inflammatory cells that lead to plaque formation and occurs when a condition called atherosclerosis occurs. This plaque can create an obstruction (called a stenosis) to the normal supply of oxygenated blood to the heart muscle, which can cause chest pain (angina) and eventually, cardiac arrest. [0003] The field of interventional cardiology is the branch of cardiology that is specifically concerned with catheter-based treatment of structural heart disease, such as CAD. One type of interventional cardiology pr...

AI Technical Summary

Problems solved by technology

One problem with this approach is that the artery may appear tapered or assume some complex geometry for which a purely cylindrical strut-shaped structure may not be suitable to maintain contact with the arterial wall in the apposition state

Therefore, the difference between off-the-shelf stent geometry and patient-specific geometry can be significant, leading to complications due to malapposition and incorrect sizing

These differences are on the order of tens to hundreds of microns, but currently employed techniques do not provide finer control over tolerances

Lack of contact between stent and arterial wall (malapposition) can generate complex patterns of low wall shear stress (friction of flowing blood on the arterial wall), resulting in cell proliferation that can lead to ISR and ST

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