Treatment model for osteoarthritis by human adipose-derived stem cells and treatment method thereof

An adipose-derived stem cell and osteoarthritis technology, applied in the field of cell engineering, can solve the problems of insufficient control stability of stem cell therapy, uncontrollable changes in various processes, poor induction and differentiation effect, etc. and differentiation effect, the effect of enhancing the therapeutic effect

Inactive Publication Date: 2020-03-24
YANTAI ZHIXING INTPROP CONSULTATION SERVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Clinically, only non-drug treatment and drug model treatment methods can relieve pain and delay function loss, so as to improve the quality of life of patients, but the treatment effect is not good. With the continuous development and popularization of stem cell research, more and more More and more researchers have extended stem cell technology to the treatment of osteoarthritis, but there are still defects such as poor induction of differentiation, insufficient control stability of stem cell therapy, and uncontrollable changes in various processes, which need further analysis and improvement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A human-derived adipose stem cell treatment model and treatment method for osteoarthritis, the model treatment method includes the following steps:

[0053] P1. Preparation of stem cell injection: select human-derived adipose tissue, break it up and separate the oil layer to prepare stem cell injection;

[0054] P2. Establishment of osteoarthritis model: Select 6-week-old experimental white mice and inject induction solution into the knee joint cavity for 1 week to induce knee arthritis and establish an osteoarthritis model;

[0055] P3. Model separation: the osteoarthritis model mice were divided into two groups, which were respectively coded as local injection model mice and intravenous injection model mice;

[0056] P4. Intervention treatment: Intervention treatment for local injection of model mice, local injection of stem cell injection at the site of osteoarthritis induction, intravenous injection of stem cell injection for intravenous injection of model mice, and...

Embodiment 2

[0074] A human-derived adipose stem cell treatment model and treatment method for osteoarthritis, the model treatment method includes the following steps:

[0075] P1. Preparation of stem cell injection: select human-derived adipose tissue, break it up and separate the oil layer to prepare stem cell injection;

[0076] P2. Establishment of osteoarthritis model: Select 8-week-old experimental white mice and inject induction solution into the knee joint cavity for 2 weeks to induce knee arthritis and establish an osteoarthritis model;

[0077] P3. Model separation: the osteoarthritis model mice were divided into two groups, which were respectively coded as local injection model mice and intravenous injection model mice;

[0078] P4. Intervention treatment: Intervention treatment for local injection of model mice, local injection of stem cell injection at the induction site of osteoarthritis, intravenous injection of stem cell injection for intravenous injection of model white mi...

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PUM

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Abstract

The invention discloses a treatment model for osteoarthritis by human adipose-derived stem cells and a treatment method thereof. The treatment method of the model comprises the following steps: P1, preparing a stem cell injection; P2, establishing an osteoarthritis model; P3, performing model separation; P4, performing interventional therapy; P5, performing tissue observation; P6, performing result statistics; and P7, performing contrast. The invention provides the treatment model for osteoarthritis by human adipose-derived stem cells and the treatment method thereof, the tubular joint induction is carried out on an experimental white mouse, the joint tube disease position and deterioration degree can be effectively controlled, meanwhile, two different forms of local injection treatment and intravenous injection treatment are combined, the intervention result is compared and analyzed, the change process and the intervention direction can be easily controlled, meanwhile, the intervention result is archived and compared and analyzed, the optimal solution can be easily obtained, the stem cell effect and differentiation effect are improved, the treatment effect is improved, and control, use and popularization are facilitated.

Description

technical field [0001] The invention relates to the technical field of cell engineering, in particular to a treatment model and treatment method of human adipose stem cells on osteoarthritis. Background technique [0002] Primary knee osteoarthritis is a common degenerative joint disease in middle-aged and elderly people. Knee pain, stiffness, and limitation of motion are present and warrant treatment. [0003] Clinically, only non-drug treatment and drug model treatment methods can relieve pain and delay function loss, so as to improve the quality of life of patients, but the treatment effect is not good. With the continuous development and popularization of stem cell research, more and more More and more researchers have extended stem cell technology to the treatment of osteoarthritis, but there are still defects such as poor induction of differentiation, insufficient control stability of stem cell therapy, and uncontrollable changes in various processes, which need furth...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61P19/02A61P19/08A61K49/00
CPCA61K35/28A61K49/0008A61P19/02A61P19/08
Inventor 李从宾
Owner YANTAI ZHIXING INTPROP CONSULTATION SERVICES CO LTD
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