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Simulated respiratory tract

A respiratory and gas technology, applied in the field of simulated respiratory tract, can solve problems such as low settlement efficiency

Pending Publication Date: 2020-03-24
PHILIP MORRIS PROD SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially nano-sized aerosol particles may require electrostatic attraction due to their low settling efficiency

Method used

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  • Simulated respiratory tract
  • Simulated respiratory tract
  • Simulated respiratory tract

Examples

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Embodiment Construction

[0162]In certain embodiments, the practice of the present disclosure employs conventional techniques of engineering, microbiology, cell biology, and biochemistry. Biological techniques are fully explained in, for example, Molecular Cloning: A Laboratory Manual, Second Edition (Sambrook et al., 1989) Cold Spring Harbor Press; Oligonucleotide Synthesis. )" (MJ.Gait editor, 1984); "Molecular Biology Methods (Methods in Molecular Biology)", Humana Press; "Cell Biology: A Laboratory Notebook" (J.E.CeIMs editor, 1998) Academic Press; "Animal Cell Culture" (Edited by R.I.Freshney, 1987); "Introduction to Cell and Tissue Culture" (J.P.Mather and P.E.Roberts, 1998) Plenum Press; Tissue Culture Laboratory Procedures (Cell and Tissue Culture: Laboratory Procedures)" (A.Doyle, IB.Griffiths, and D.G.Newell edited, 1993-8) J.Wiley and Sons; "Methods in Enzymology" (Academic Press, Inc.); "Current Protocols in Molecular Biology" (Edited by F.M.Ausubel et al., 1987); "PCR: The Polymerase Cha...

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Abstract

There is described herein a system for determining the interaction between a test atmosphere and a simulated respiratory tract, said system comprising: (a) a first pump comprising: (i) a chamber configured for containing a first volume of gas comprising a test atmosphere; (ii) a first port adapted for receiving and outputting gas and comprising a valve for regulating the flow of gas through the first port, said valve being moveable between open and closed positions, wherein in the open position said valve is openable towards a test atmosphere or surrounding air; (iii) a second port adapted foroutputting and receiving gas and comprising a valve for regulating the flow of gas through the second port, said valve being moveable between open and closed positions; (iv) a piston plate in the chamber, said piston plate comprising one or more apertures for the uptake or inflow of gas into the chamber wherein one or more, or each, of the apertures include a valve that is movable between open and closed positions and is capable of regulating the uptake or inflow of gas; (b) a second pump comprising: (i) a chamber configured for containing a second volume of gas, wherein the first and secondvolumes of gas are different; (ii) a port adapted for receiving and outputting gas; and (iii) a motor for controlling the operation of the second pump; (c) a connecting structure operable to transmitthe gas from the first pump into the second pump; and (d) one or more openings in the first pump or the second pump or the walls of the connecting structure or a combination of two or more thereof, said openings being capable of receiving a module for containing a cell culture medium or for monitoring conditions in the chamber or for gas sampling or for gas characterisation.

Description

technical field [0001] In particular, the present invention relates to devices, systems, methods and uses related to simulating the structure and / or function of the airway and its breathing behavior. The present invention is useful for studying the interaction between a test agent (eg, an inhalable agent in the test atmosphere) and the respiratory tract. In particular, the invention relates to modeling the human airway. Background technique [0002] The respiratory system travels from the nose and upper airways to the alveolar surfaces of the lungs, where gas exchange occurs. Inhaled aerosols travel from the mouth through the upper airways, eventually reaching the alveoli. As the aerosol moves deeper into the airways, more soluble gas is absorbed and aerosol particles are deposited deep in the airways and alveoli. A particular aerosol of interest in the context of the present invention is smoke, such as tobacco smoke, since the effect of smoke on or through a simulated ai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/36C12M1/34C12M1/04C12M1/00C12Q1/02F04B35/04F04B49/22A24F40/80
CPCA24C5/3406A24F40/80G09B23/288A24F42/90A24C5/34C12N5/0697F04B39/10G01N33/5005G09B23/32F04B19/04F04B37/20
Inventor P·赫维S·马吉德S·斯坦纳
Owner PHILIP MORRIS PROD SA